Current Topics in Microbiology and Immunology

The Third Component of Complement

Chemistry and Biology

Editors: Lambris, John D. (Ed.)

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About this book

The third component of complement, C3, is one of the most versatile proteins and an important participant in immune surveillance and immune response pathways. Its multifunctio­ nality is based on its ability to interact specifically with multiple serum complement proteins, cell surface receptors, and mem­ brant;-associated regulatory proteins. One of its most intriguing strategies of interaction with cell surfaces is the covalent binding of activated C3 through the internal thioester. The field has expanded over the past 10 years and a wealth of information has accumulated. C3 from various species and many of the human C3 binding proteins have been cloned and expressed. Numerous cellular responses mediated by the diffe­ rent fragments of C3 have been described. The findings that C3 interacts in a ligand-receptor-like fashion with proteins of nonself origin such as the gC of herpes simplex virus, a 70-kDa protein from Candida albicans, proteins from Epstein-Barr virus, etc. has opened a new field of investigation. The papers assembled in this volume summarize the wealth of data on the various aspects of the C3 interactions; together they bring to the reader new information on the chemistry, molecular gene­ tics, biology, and pathophysiology of C3 and C3-binding proteins. Emphasis is given to structural features as they relate to functions. Spring 1989 JOHN D. LAMBRIS, HANS J. MULLER-EBERHARD Table of Contents J. E. VOLANAKIS: Participation of C3 and Its Ligands in Complement Activation . . . . . . . . . . . 1 S. R. BARNUM, G. FEY, and B. F. TACK: Biosynthesis and Genetics of C3 . . . . . . . . . . . . .

Table of contents (13 chapters)

  • Participation of C3 and its Ligands in Complement Activation

    Volanakis, J. E.

    Pages 1-21

  • Biosynthesis and Genetics of C3

    Barnum, S. R. (et al.)

    Pages 23-43

  • Molecular Aspects of C3 Interactions and Structural/Functional Analysis of C3 from Different Species

    Becherer, J. D. (et al.)

    Pages 45-72

  • The Thioester Bond of C3

    Levine, R. P. (et al.)

    Pages 73-82

  • Complement Receptor Type 1 (C3b/C4b Receptor; CD35) and Complement Receptor Type 2 (C3d/Epstein-Barr Virus Receptor; CD21)

    Fearon, D. T. (et al.)

    Pages 83-98

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-74977-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-74979-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Third Component of Complement
Book Subtitle
Chemistry and Biology
Editors
  • John D. Lambris
Series Title
Current Topics in Microbiology and Immunology
Series Volume
153
Copyright
1990
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-74977-3
DOI
10.1007/978-3-642-74977-3
Softcover ISBN
978-3-642-74979-7
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IX, 251
Number of Illustrations and Tables
10 b/w illustrations
Topics