Current Topics in Microbiology and Immunology

The Scid Mouse

Characterization and Potential Uses

Editors: Bosma, Melvin J., Phillips, Robert A., Schuler, Walter (Eds.)

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About this book

During routine genetic screening of several immunoglobulin heavy chain congenic mouse strains in 1980, one of us (MB) was surprised to find that several mice in the C.B-17IIcr strain, which was being maintained in a specific-pathogen-free facility of the Fox Chase Cancer Center (Philadelphia, PA), did not express serum immunoglobulin of the appropriate allotype. Fearing an error in the breeding of these mice, the sera of the suspect mice were screened for other allotypes. When these tests revealed a complete absence of serum immunoglobulin, it became apparent that a mutation had probably occurred in the C.B-17IIcr line. Further analysis revealed that a single breeding pair was respon­ sible for all of the immunoglobulin negative mice and that the defect showed recessive inheritance. Thus was the C.B-17/Icr scid or severe combined immune deficient (scid) mouse discovered. Although it has taken most animal facilities several years to breed scid mice of high quality for experimental purpose, it was clear by 1987 that many investigators were beginning to exploit the unique qualities of the scid mouse for studies in several areas.

Table of contents (31 chapters)

Table of contents (31 chapters)
  • The

    Pages 3-9

    Bosma, Melvin J.

  • Pleiotropic Effects of the

    Pages 11-17

    Phillips, R. A. (et al.)

  • Analysis of Lymphoid Population in Scid Mice; Detection of a Potential B Lymphocyte Progenitor Population Present at Normal Levels in Scid Mice by Three Color Flow Cytometry With B220 and S7

    Pages 19-25

    Hardy, R. R. (et al.)

  • Phenotype and Differentiation Stage of Scid Mouse Thymocytes

    Pages 27-32

    Habu, Sonoko (et al.)

  • Growth Requirements of B Lineage Lymphocytes From Scid and Normal Mice

    Pages 33-37

    Lee, G. (et al.)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-642-74974-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-74976-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
The Scid Mouse
Book Subtitle
Characterization and Potential Uses
Editors
  • Melvin J. Bosma
  • Robert A. Phillips
  • Walter Schuler
Series Title
Current Topics in Microbiology and Immunology
Series Volume
152
Copyright
1989
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-74974-2
DOI
10.1007/978-3-642-74974-2
Softcover ISBN
978-3-642-74976-6
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XII, 263
Topics