Handbook of Experimental Pharmacology

Microbial Resistance to Drugs

Editors: Bryan, Lawrence E. (Ed.)

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About this book

Most often when the subject of antimicrobial resistance is discussed, the organizational emphasis is on individual antimicrobial agents or groups of agents. Thus we tend to see discussion of resistance to f3-lactams, tetracyclines, amino­ glycosides etc. In this book many of the authors were asked to emphasize the mechanism of resistance in their discussion and from that to show how susceptibility to various agents was affected. In part this was done to help emphasize the enormous contribution that the study of antimicrobial resistance has made to our understanding of fundamental physiologic and genetic processes in bacteria. When one looks back over the study of antimicrobial resistance, it is clear that it has been the birthplace of many fundamental advances in molecular biology and of an appreciation of the role of many key functions in the life of a bacterium. In addition, and hopefully to an increasing extent in the future, such study has also contributed to advances in antimicrobial chemotherapy. Through­ out the book resistance mechanisms have been placed in perspective as to their significance as causes of resistance to key drugs or groups of drugs. Some are of much greater significance than others in terms of the prevalence or the degree of resistance produced. Whatever their numerical significance, however, each of the mechanisms, without question, throws light on fundamental cellular processes and the way in which they interact with antimicrobial agents.

Table of contents (18 chapters)

  • Role of the Outer Membrane of Gram-Negative Bacteria in Antimicrobial Resistance

    Nikaido, H.

    Pages 1-34

  • Cytoplasmic Membrane Transport and Antimicrobial Resistance

    Bryan, L. E.

    Pages 35-57

  • Susceptibility and Resistance of Plasmodium falciparum to Chloroquine

    Krogstad, D. J. (et al.)

    Pages 59-75

  • Resistance to β-Lactam Antibiotics Mediated by Alterations of Penicillin-Binding Proteins

    Spratt, B. G.

    Pages 77-100

  • Plasmid-Determined Beta-Lactamases

    Medeiros, A. A.

    Pages 101-127

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-74095-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-74097-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Microbial Resistance to Drugs
Editors
  • Lawrence E. Bryan
Series Title
Handbook of Experimental Pharmacology
Series Volume
91
Copyright
1989
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-74095-4
DOI
10.1007/978-3-642-74095-4
Softcover ISBN
978-3-642-74097-8
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XVII, 451
Topics