New Concepts in Viral Heart Disease

1. Front Matter

   Pages I-XI

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2. Epidemiology and Natural History

   1. Front Matter

      Pages 1-1

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   2. Etiology, Pathogenesis, and Pathophysiology of Dilated Cardiomyopathies

      • W. H. Abelmann

      Pages 3-21

   3. Virological, lmmunological and Clinical Features of Myocarditis and Dilated Cardiomyopathy

      • J. F. Goodwin

      Pages 22-25

   4. Epidemiology and Pathogenicity of Coxsackieviruses

      • N. R. Grist

      Pages 26-32

   5. Natural History of Acute Viral or Idiopathic Myocarditis: A Clinical and Endomyocardial Biopsy Follow-up

      • M. Sekiguchi, M. Hiroe, S. Hiramitusu, T. Izumi

      Pages 33-50

   6. Myocarditis in Patients with Dilated Cardiomyopathy — Correlation with Clinical, Hemodynamic, and Biochemical Findings

      • V. Regitz, R. Strasser, G. Chmielewski, S. Blümcke, E. Fleck

      Pages 51-60

   7. Coxsackievirus Cardiomyopathy in Animal Models, Including the Augmenting Effect of Exercise During the Acute Phase

      • M. P. Reyes, A. M. Lerner, R. Khatib

      Pages 61-69

3. Concepts in Viral Pathogenesis

   1. Front Matter

      Pages 71-71

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   2. Replication, Molecular Biology, and Pathogenesis of Coxsackieviruses

      • N. K. Chatterjee

      Pages 73-78

   3. A Murine Model for Coxsackievirus B3-Induced Acute Myocardial Necrosis for Study of Cellular Receptors as Determinants of Viral Tropism

      • R. L. Crowell, S. D. Finkelstein, K.-H. L. Hsu, B. J. Landau, P. Stalhandske, P. S. Whittier

      Pages 79-92

   4. Induction of Soluble Mediators During Coxsackievirus B3 Replication In Vitro and In Vivo

      • C. J. Gauntt, C. W. Lutton, G. E. Revtyak, A. J. Valente, A. N. Fernandes, H. M. Arizpe et al.

      Pages 93-104

   5. Persistence of Echovirus Type 6 in Cultured Cells

      • V. F. Righthand

      Pages 105-114

   6. Detection and Typing of Enteroviruses by Nucleic Acid Probes and Monoclonal Antibodies

      • T. Hyypiä, M. Kallajoki, P. Auvinen

      Pages 115-124

   7. Generation of Enterovirus Group-Specific Antisera Using Bacterially Synthesized Coxsackievirus B3 Proteins

      • S. Werner, H. Schönke, W. Klump, P. H. Hofschneider, R. Kandolf

      Pages 125-136

4. Virus and Immunity

   1. Front Matter

      Pages 137-137

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   2. Myocarditis: A Postinfectious Autoimmune Disease

      • N. R. Rose, N. Neu, D. A. Neumann, A. Herskowitz

      Pages 139-147

   3. Viral Myocarditis: Immunogenetic and Autoimmune Aspects

      • K. W. Beisel, M. D. Traystman

      Pages 148-159

   4. Is Coxsackievirus B3-Induced Myocarditis in A/J Mice Mediated by an Autoimmune Response to Cardiac Myosin?

      • N. Neu, G. Krömer, B. Ploier, N. R. Rose

      Pages 160-167

   5. Virus-Induced Autoimmunity: Cross-Reactivity of Antiviral Antibodies with Self-Components

      • B. S. Prabhakar, J. Srinivasappa, K. W. Beisel, A. L. Notkins

      Pages 168-178

The recent rapid advances in our knowledge of immunological and virological mechanisms involved in the pathogenesis of viral heart disease makes it difficult for everybody working in this field to keep up with the latest developments. How­ ever, much of what we know is still circumstantial and only vaguely substained. Interdisciplinary understanding and cooperation thus seems necessary to get a better insight into the mechanisms by which viruses may initiate immunological organ-specific tissue injury and disease! This volume evolved out of an international symposium by the same title held on May 25. -28. , 1988 in Tegernsee, near Munich, of which a wide spectrum ofim­ munological, virological, diagnostical and clinical problems was covered. Both review articles and new experimental and clinical data are included in this volume to give the reader an up-to-date information about current concepts and future aspects. Chapter I serves as an excellent introduction to the epidemiology and natural history of dilated cardiomyopathy / viral heart disease. Although a definite viral etiology in myocarditis and dilated cardiomyopathy is often difficult to establish, epidemiological and serological data incriminate a viral etiology underlying many cases of "dilated cardiomyopathy". Chapters II and III describe the current think­ ing on virological and immunological mechanisms involved in the pathogenesis of viral heart disease. Among others virus topism, virus persistance, possible mecha­ nisms and genetic basis of post-infection autoimmunity, and the virus-interaction with the immune system are discussed.

• antibody
• antigen
• autoimmune disease
• biopsie
• biopsy
• heart
• histocompatibility
• molecular biology
• necrosis
• pathogenesis
• pathophysiology
• transplantation
• virus

• Med. Klinik I, Klinikum Großhadern, München 70, Germany

  Heinz-Peter Schultheiß

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