Handbook of Experimental Pharmacology

Antituberculosis Drugs

Editors: Bartmann, Karl (Ed.)

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About this book

This volume deals specifically with those antituberculosis drugs which passed the preclinical phase and have been or are used in the treatment of tuberculosis and other mycobacterial diseases (except leprosy) in at least some parts of the world. Despite this restriction, there are 14 such drugs, and as a result this volume has reached rather large proportions. To prevent it from becoming even larger and more unwidely, most derivatives of antituberculotics have been omitted, especially where it is claimed that they provide only better bioavailibility or tolerability. Only in the chapter on the chemotherapy of diseases due to so-called atypical mycobacteria is the clinical use of the drugs described to a certain extent. In addition to antituberculotics, also discussed are antimicrobials which have been found to be effective against these mycobacteria. The sequence in which the drugs are described is historical, reflecting not the time of discovery but rather the first clinical application. This order was selected for reasons which are now no longer relevant. In this volume less emphasis is placed on detection, biological or synthetic production of antituberculotics, and structure-activity relationships. In contrast, emphasis is put on the degree, type, and mechanism of antimyco bacterial activity, pharmacokinetics, and biotransformation in animals and man, on experimental pharmacodynamics, and on the toxicity of antituberculotics used therapeutically.

Table of contents (6 chapters)

  • Historical Introduction and Chemical Characteristics of Antituberculosis Drugs

    Offe, H. A.

    Pages 1-30

  • Experimental Evaluation of Efficacy

    Trnka, L. (et al.)

    Pages 31-232

  • Experimental Evaluation of Chemoprophylaxis and Preventive Treatment in Animals

    Kleeberg, H. H.

    Pages 233-258

  • Experimental and Clinical Activity of Antituberculosis Drugs and Other Antimicrobial Agents Against Mycobacteria Other than Tubercle Bacilli, Except M. Leprae

    Bartmann, K.

    Pages 259-306

  • Experimental Pharmacology and Toxicology of Antituberculosis Drugs

    Tettenborn, D.

    Pages 307-398

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-3-642-72873-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-3-642-72875-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Antituberculosis Drugs
Editors
  • Karl Bartmann
Series Title
Handbook of Experimental Pharmacology
Series Volume
84
Copyright
1988
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-72873-0
DOI
10.1007/978-3-642-72873-0
Softcover ISBN
978-3-642-72875-4
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XXIV, 566
Topics