The Sodium Pump

Structure Mechanism, Hormonal Control and its Role in Disease

Editors: Bamberg, Ernst, Schoner, Wilhelm (Eds.)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-72511-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.99
price for USA in USD
  • ISBN 978-3-642-72513-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The sodium of animal cell membranes converts the chemical energy obtained from the hydrolysis of adenosine 5' -triphosphate into a movement of the cations Na + and K + against an electrochemical gradient. The gradient is used subse­ quently as an energy source to drive the uptake of metabolic substrates in polar epithelial cells and to use it for purposes of communications in excitable cells. The biological importance of the sodium pump is evident from the fact that be­ tween 20-70% of the cell's metabolic energy is consumed for the pumping pro­ cess. Moreover, the sodium pump is an important biological system involved in regulatory processes like the maintenance of the cells' and organism's water me­ tabolism. It is therefore understandable that special cellular demands are han­ dled better by special isoforms of the sodium pump, that the expression of the sodium pump and their isoforms is regulated by hormones as is the activity of the sodium pump via hormone-regulated protein kinases. Additionally, the sodium pump itself seems to be a receptor for a putative new group of hormones, the endogenous digitalis-like substances, which still have to be defined in most cases in their structure. This group of substances has its chemically well known coun­ terpart in steroids from plant and toad origin which are generally known as "car­ diac glycosides". They are in medical use since at least 200 years in medicine in the treatment of heart diseases.

Table of contents (49 chapters)

  • Transcription factors regulating the Na+/K+-ATPase genes

    Kawakami, K. (et al.)

    Pages 1-10

  • Expression of Functional Na+/K+-ATPase in Yeast

    Farley, Robert A. (et al.)

    Pages 11-20

  • Expression of Functional Na+/K+-ATPase in Insect Cells Using Baculovirus

    Mercer, R. W. (et al.)

    Pages 21-32

  • Sp1 and an E-Box Binding Protein Regulate Na+/K+-ATPase α2-Subunit Gene

    Ikeda, K. (et al.)

    Pages 33-36

  • Cloning and Analysis of the 5’-Flanking Region of the Rabbit Na+/K+-ATPase α2 Subunit Gene

    Kjærsig, Trine (et al.)

    Pages 37-40

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-72511-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.99
price for USA in USD
  • ISBN 978-3-642-72513-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
The Sodium Pump
Book Subtitle
Structure Mechanism, Hormonal Control and its Role in Disease
Editors
  • Ernst Bamberg
  • Wilhelm Schoner
Copyright
1994
Publisher
Steinkopff-Verlag Heidelberg
Copyright Holder
Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt
eBook ISBN
978-3-642-72511-1
DOI
10.1007/978-3-642-72511-1
Softcover ISBN
978-3-642-72513-5
Edition Number
1
Number of Pages
XX, 906
Topics