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Cellular and Molecular Alterations in the Failing Human Heart

Editors: Just, H., Hasenfuss, G., Holubarsch, C., Alpert, N.R. (Eds.)

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About this book

The myocardium in heart failure: Cellular and subcellular alterations in the failing human myocardium. H. Just Medizinische Universitatsklinik Freiburg i. Br., Innere Medizin III - Kardiologie, FRG The syndrome of heart failure continues to be a major challenge to clinicians and scientists. Incidence and mortality of the disease are high, the patient is disabled, and is permanently threatened by the high morbidity and mortality. The clinician faces a syndrome of complex pathophysiology. Multiple causes or underlying disorders of the heart have to be differentiated from heart failure itself, which often results in exceedingly difficult diagnoses. Likewise, prognostication meets with difficulties due to problems in separating influences of the underlying disease and the heart failure syndrome itself. In chronic refractory failure annual mortality may exceed 50%. If aortic stenosis or ischemic cardiomyopathy with main­ stem lesions are present, this percentage may be even higher. The situation becomes particularly threatening to the patient when the reduction in cardiac performance goes along with complex ventricular arrhythmias. Therapy has remained difficult and of limited effectiveness. Major progress was achieved with the introduction of diuretic substances. Of similar importance was the introduction of va so dilating drugs into the treatment of heart failure. The principle of vasodilation has greatly improved our understanding of the disease, and has brought about a major improvement of symptoms, increase of exercise capacity, and reduc­ tion of mortality. This is especially true for the introduction of the angiotensin converting enzyme inhibitors.

Table of contents (29 chapters)

  • Receptor systems in the non-failing human heart

    Brodde, Prof. Dr. Otto-Erich (et al.)

    Pages 1-14

  • Changes in the receptor-G protein-adenylyl cyclase system in heart failure from various types of heart muscle disease

    Bristow, Michael R., MD, PhD (et al.)

    Pages 15-35

  • Quantification of Giα-proteins in the failing and nonfailing human myocardium

    Böhm, Dr. M. (et al.)

    Pages 37-50

  • Regulation and possible functional implications of G-protein mRNA expression in nonfailing and failing ventricular myocardium

    Eschenhagen, Dr. med. T. (et al.)

    Pages 51-64

  • Phosphodiesterase inhibition and positive inotropy in failing human myocardium

    Schmitz, Prof. Dr. W. (et al.)

    Pages 65-71

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-72474-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.00
price for USA in USD
  • ISBN 978-3-642-72476-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cellular and Molecular Alterations in the Failing Human Heart
Editors
  • Hansjörg Just
  • Gerd Hasenfuss
  • Christian Holubarsch
  • N.R. Alpert
Copyright
1992
Publisher
Steinkopff-Verlag Heidelberg
Copyright Holder
Dr. Dietrich Steinkopff Verlag GmbH & Co.KG, Darmstadt
eBook ISBN
978-3-642-72474-9
DOI
10.1007/978-3-642-72474-9
Softcover ISBN
978-3-642-72476-3
Edition Number
1
Number of Pages
XII, 344
Topics