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Current Topics in Microbiology and Immunology

Clinical Applications of Immunotoxins

Editors: Frankel, Arthur E. (Ed.)

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About this book

1 2 D. FITZGERALDI, I. PASTAN , and J. ROBERTUS Introduction . . . . . . . . . . . . . I 2 Toxin Structure-Function Properties 2 2. 1 Functions. . . . . . . . . . . . . . . . . . . . . . . . 2 2. 2 Binding. . . . . . . . . . . . . . . . . . . . . . . . . 3 3 Intracellular Processing - Cleavage and Reduction . . . . . . 4 3. 1 Cytosolic Activity . . . . . . . . . . . . . . . . 5 4 Immunotoxin Design and Testing. 6 5 Conclusion. . 8 References. . . . . 8 1 Introduction While various treatment approaches for cancer include reversal of the transformed phenotype, stimulation of immune responses, inhibition of metastatic spread and deprivation of key nutrients, the goal of immunotoxin treatment is the direct killing of malignant cells. Because they are enzymatic proteins that act catalytically to kill cells, bacterial and plant toxins are often employed as the cell-killing component of immunotoxins. Here we provide background information into the structure-func­ tion relationships of toxins and discuss how they can be combined with cell-binding antibodies or other ligands to generate immunotoxins. Bacterial and plant toxins (e. g. , diphtheria toxin, Pseudomonas exotoxin and ricin) are among the most toxic substances known. However, because they bind to cell surface receptors that are present on most normal cells, unmodified toxins are generally useless as anti-cancer agents. To convert toxins into more selective agents, their binding domains are either eliminated or disabled and replaceq with cell­ binding antibodies that are tumor-selective.

Table of contents (8 chapters)

  • Introduction

    FitzGerald, I. (et al.)

    Pages 1-11

  • The Emerging Role of Ricin A-Chain Immunotoxins in Leukemia and Lymphoma

    Engert, A. (et al.)

    Pages 13-33

  • Clinical Trials with Blocked Ricin Immunotoxins

    O’Toolei, J. E. (et al.)

    Pages 35-56

  • Saporin Immunotoxins

    Flavell, D. J.

    Pages 57-61

  • Diphtheria Toxin Fusion Proteins

    Foss, F. M. (et al.)

    Pages 63-81

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-72153-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-72155-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Clinical Applications of Immunotoxins
Editors
  • Arthur E. Frankel
Series Title
Current Topics in Microbiology and Immunology
Series Volume
234
Copyright
1998
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-72153-3
DOI
10.1007/978-3-642-72153-3
Softcover ISBN
978-3-642-72155-7
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IX, 122
Number of Illustrations and Tables
5 b/w illustrations, 1 illustrations in colour
Topics