Current Topics in Microbiology and Immunology

Leukocyte Integrins in the Immune System and Malignant Disease

Editors: Holzmann, Bernhard, Wagner, Hermann (Eds.)

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  • The book focuses on leukocyte integrins, in particular, on receptors of the alpha4 subfamily.

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About this book

Most lymphocytes recirculate throughout the body, migrating from blood through organized lymphoid tissues such as lymph nodes (LN) and Peyer's patches (PP), then to lymph and back to blood (GOWANS and KNIGHT 1964). Smaller numbers of lymphocytes migrate from blood to extranodal tissues such as pancreas and then through lymphatic vessels to LN (MACKAY et al. 1990). An important feature of this migration is the ability of lymphocytes to recognize and adhere to the surface of blood vessel endothelial cells before migrating through the vessel wall into surrounding tissue (CARLOS and HARLAN 1994; IMHOF and DUNON 1995; BUTCHER and PICKER 1996). Adhesion interactions of vascular endothelium with lymphocytes under flow or shear consist of at least four steps: (I) an initial transient sticking or rolling; (2) if the lymphocytes encounter appropriate activating or chemotactic factors in the local environment, rolling may be followed by a lymphocyte activation step that then leads to; (3) strong adhesion or sticking that may be followed by; (4) lym­ phocyte diapedesis into tissue (BUTCHER 1991; SHIMUZU et al. 1992; SPRINGER 1994; BARGATZE et al. 1995). Specific lymphocyte and endothelial adhesion molecules (AM) are involved in each step of this "adhesion cascade" (reviewed in CARLOS and HARLAN 1994; IMHOF and DUNON 1995; BUTCHER and PICKER 1996). This allows lymphocyte migration to be controlled at several different steps, leading to a combinatorial increase in specificity and sensitivity.

Table of contents (10 chapters)

Table of contents (10 chapters)
  • VLA-4-Mediated Signaling

    Pages 1-22

    Morimoto, C. (et al.)

  • Functions of α4- and β7-Integrins in Hematopoiesis, Lymphocyte Trafficking and Organ Development

    Pages 23-32

    Wagner, N. (et al.)

  • Regulation of Integrin Function by Inside-Out Signaling Mechanisms

    Pages 33-49

    Kolanus, W. (et al.)

  • The Role of α4-Integrin in T Lymphocyte Migration Into the Inflamed and Noninflamed Central Nervous System

    Pages 51-64

    Engelhardt, B.

  • The Roles of α4-Integrins in the Development of Insulin-Dependent Diabetes Mellitus

    Pages 65-83

    Michie, S. A. (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-3-642-71987-5
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-3-642-71989-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Leukocyte Integrins in the Immune System and Malignant Disease
Editors
  • Bernhard Holzmann
  • Hermann Wagner
Series Title
Current Topics in Microbiology and Immunology
Series Volume
231
Copyright
1998
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-71987-5
DOI
10.1007/978-3-642-71987-5
Softcover ISBN
978-3-642-71989-9
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VIII, 189
Topics