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Cyclin Dependent Kinase (CDK) Inhibitors

  • Book
  • © 1998

Overview

Editors:
  1. Peter K. Vogt

    1. Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA

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  2. Steven I. Reed

    1. Department of Molecular Medicine, MB-7, The Scripps Research Institute, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  • The book is dedicated to the newly characterized class of proteins known as cyclin-dependent kinase inhibitors.
  • It is the first comprehensive collection of review articles on this topic.
  • The book will, therefore, constitute a valuable resource for anyone wishing or requiring to become knowledgeable on the cell cycle, cell proliferation and tumorigenesis.

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 227)

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Table of contents (8 chapters)

  1. Front Matter

    Pages I-XI
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  2. Cyclin-Dependent Kinase Inhibitors of Saccharomyces cerevisiae and Schizosaccharomyces pombe

    • M. D. Mendenhall
    Pages 1-24

  3. Inhibitors of the Cip/Kip Family

    • L. Hengst, S. I. Reed
    Pages 25-41

  4. The INK4 Family of CDK Inhibitors

    • A. Carnero, G. J. Hannon
    Pages 43-55

  5. Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development

    • S. P. Chellappan, A. Giordano, P. B. Fisher
    Pages 57-103

  6. Roles of Cyclin-Dependent Kinase Inhibitors: Lessons from Knockout Mice

    • H. Kiyokawa, A. Koff
    Pages 105-120

  7. p21/p53, Cellular Growth Control and Genomic Integrity

    • W. S. El-Deiry
    Pages 121-137

  8. Cyclin-Dependent Kinase Inhibitors and Human Cancer

    • A. Kamb
    Pages 139-148

  9. Small-Molecule Inhibitors of Cyclin-Dependent Kinases: Molecular Tools and Potential Therapeutics

    • D. H. Walker
    Pages 149-165

  10. Back Matter

    Pages 167-172
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Keywords

About this book

More than 10 years ago, the discovery of cyclin-dependent ki­ nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg­ ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led to a simple model for cell cycle control. Modulation of cyclin accumulation, and thereby Cdk activation, was proposed to be the overarching principle governing the passage through cell cycle phases. An­ other reality to emerge from the discovery of Cdks was the ex­ ceptional degree of evolutionary conservation maintained in the machinery and organization of proliferation control. Not only were Cdks shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle control and the role and regulation of Cdks. The uncritical enthusiasm with which many of the ideas were em­ braced has required tempering. For example, although Cdks appear to be highly conserved phylogenetically, cyclins are much less so.

Editors and Affiliations

  • Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA

    Peter K. Vogt

  • Department of Molecular Medicine, MB-7, The Scripps Research Institute, La Jolla, USA

    Steven I. Reed

Bibliographic Information

  • Book Title: Cyclin Dependent Kinase (CDK) Inhibitors

  • Editors: Peter K. Vogt, Steven I. Reed

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-71941-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1998

  • Softcover ISBN: 978-3-642-71943-1Published: 30 December 2011

  • eBook ISBN: 978-3-642-71941-7Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XII, 169

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Immunology, Cell Biology, Cancer Research, Biochemistry, general

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