Prostaglandins in Cancer Research

1. Front Matter

   Pages I-XI

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2. Introductory Lectures

   1. Front Matter

      Pages 1-1

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   2. On the Formation and Biological Role of Leukotrienes and Lipoxins

      • B. Samuelsson, C. Serhan

      Pages 3-11

   3. Anti-Inflammatory Drugs and the Arachidonic Acid Cascade

      • J. R. Vane

      Pages 12-25

3. Carcinogenesis

   1. Front Matter

      Pages 27-27

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   2. Icosanoids, Chromosome Damage and Cancer

      • I. Emerit

      Pages 29-34

   3. The Arachidonate Cascade and Mouse Skin Tumor Promotion

      • S. M. Fischer

      Pages 35-47

   4. Modulation of the Conversion Stage of Multistep Carcinogenesis in Mouse Skin by Eicosanoids

      • G. Fürstenberger, M. Gschwendt, H. Hagedorn, F. Marks

      Pages 48-61

   5. Tumor Promoters, Growth Factors and Arachidonic Acid Metabolism

      • L. Levine

      Pages 62-73

4. Cellular and Molecular Mechanisms of PG Action

   1. Front Matter

      Pages 75-75

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   2. Prostaglandins and Calcium Metabolism in Cancer

      • R. S. Bockman, N. Hickok, B. Rapuano

      Pages 77-85

   3. Cellular Uptake and Nuclear Accumulation of Prostaglandin A and J, a Mechanism of Prostaglandin-Induced Growth Inhibition

      • S. Narumiya, K. Ohno, M. Fukushima, M. Fujiwara

      Pages 86-96

   4. Involvement of Protein Synthesis in the Antiproliferative and the Antiviral Action of Prostaglandins

      • M. G. Santoro

      Pages 97-114

   5. The Mechanism of Prostaglandin Inhibition on the Cell Cycle

      • M. Hughes-Fulford

      Pages 115-128

   6. Interferon-Induced Modifications of the Fatty Acid Side Chains of Cell Membrane Phospholipids

      • K. A. Chandrabose, S. Agarwal

      Pages 129-137

5. Cell Proliferation and Differentiation

   1. Front Matter

      Pages 139-139

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   2. Prostaglandin Production by Tumors

      • B. M. Jaffe, M. G. Santoro

      Pages 141-150

   3. Regulation by Prostaglandins of Differentiation of Mouse Myeloid Leukemia M1 Cells

      • M. Hozumi, Y. Honma, T. Kasukabe, J. Okabe-Kado, K. Takenaga

      Pages 151-160

   4. The Role of Prostaglandins and Other Arachidonic Acid Metabolites in the Differentiation of HL-60

      • T. R. Breitman

      Pages 161-171

   5. Analysis of Platelet, Tumor Cell and Endothelial Cell Interactions in Vivo and in Vitro

      • K. V. Honn, D. G. Menter, B. W. Steinert, J. D. Taylor, J. M. Onoda, B. F. Sloane

      Pages 172-183

Arachidonic acid metabolites are known to playa regulatory role in a number of biological systems, in which they function as microenviron­ mental hormones and intracellular signal mediators. One of the most exciting areas of research of these compounds is the one that studies the relationship between prostaglandins and tumor cell growth and function. In the last few years there has been an extraordinary evolution of data on prostaglandins (and related compounds) and cancer. This vol­ ume is based on papers presented at the 1986 International Confer­ ence on Prostaglandins and Cancer organized by the Italian National Research Council and the II University of Rome, and held in Rome, Italy, in June, 1986. This Conference brought together oncologists and specialists in the areas of prostaglandin chemistry, biochemistry, pharmacology, physiology, cellular and molecular biology to overview the actual state of knowledge on the role of eicosanoids in cancer and to focus on the key questions that need to be answered. The picture that comes out of this book describes a very complicated network of interactions between arachidonic acid metabolites and different as­ pects of the complex phenomenon "cancer". Eicosanoids participate in carcinogenesis initiation and promotion, and their relationship with tumor promoters and growth factors is well established. During cancer growth, different prostaglandins can have different roles in the regulation of cell proliferation and differentiation and in metastasis formation; meanwhile evidence is accumulating for a pos­ sible use of some of these compounds as antineoplastic agents.

• biochemistry
• biology
• cancer
• cancer research
• carcinogenesis
• cell
• chemistry
• evolution
• hormones
• metastasis
• molecular biology
• pharmacology
• prostaglandins
• regulation
• tumor

• Department of Experimental Medicine, II University of Rome, Rome, Italy

  Enrico Garaci

• Institute of Pharmacological Sciences, University of Milan, Milan, Italy

  Rodolfo Paoletti

• Institute of Experimental Medicine, CNR, II University of Rome, Rome, Italy

  M. Gabriella Santoro

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