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New Aspects in Hypertension Adrenoceptors

Symposium, November 1985, Munich

  • Conference proceedings
  • © 1986

Overview

Editors:
  1. Martin Middeke

    1. Medizinische Poliklinik der Ludwig-Maximilians-Universität München, München 2, Federal Republic of Germany

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  2. Heinrich Holzgreve

    1. Medizinische Poliklinik der Ludwig-Maximilians-Universität München, München 2, Federal Republic of Germany

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Table of contents (18 papers)

  1. Front Matter

    Pages I-XII
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  2. Central Nervous Noradrenergic and Adrenergic Systems and their Functions

    • W. P. Koella
    Pages 1-13

  3. Peripheral Sympathoadrenal System: Transmitter Release and Distribution of Adrenoceptors

    • M. Göthert
    Pages 14-24

  4. Characterization of Adrenoceptors: Receptor-Binding Studies and Agonist-Antagonist Interaction

    • A. Wellstein
    Pages 25-32

  5. Agonist Interaction with α 2-Adrenoceptors of Human Platelets

    • J. Schloos, D. Palm
    Pages 33-42

  6. Regulation of the β-Adrenergic Receptor-Adenylate Cyclase System in Cardiac Membranes

    • W. Krawietz
    Pages 43-64

  7. Frequency Regulation in the Sinoatrial Node: Function of β 1- and β 2-Receptors

    • U. Borchard, D. Hafner, D. Schütz
    Pages 65-73

  8. Mechanisms of Stimulatory and Inhibitory Coupling to Adenylate Cyclase

    • M. Minuth, S. Bauer, R. Grandt, C. Greiner, P. Zubin, K. H. Jakobs
    Pages 74-80

  9. Aspects of the Pathogenesis of Essential Hypertension

    • H. Holzgreve
    Pages 81-90

  10. Sympathetic Nervous System in Essential Hypertension: Activity and Reactivity

    • T. Philipp
    Pages 91-102

  11. Adrenoceptors in Hypertension

    • M. Middeke
    Pages 103-116

  12. Adrenoceptor Alterations in Different Tissues in Human and Animal Genetic Hypertension

    • G. Bruschi, M. E. Bruschi, A. Cavatorta, A. Borghetti
    Pages 117-125

  13. Alpha2 Adrenoceptor - Mediated Alteration of Contractile Systems

    • L. H. Block
    Pages 126-132

  14. Beta Adrenoceptor Changes in Hypertension Induced by Dynamic Exercise

    • O.-E. Brodde
    Pages 133-145

  15. Effect of Fludrocortisone on Adrenoceptors and Free Intracellular Calcium in Man

    • E. Fritschka, A. Kribben, S. Harwig, H. Haller, T. Lenz, H. M. Thiede et al.
    Pages 146-154

  16. Daily Variations in the Beta-Adrenoceptor-Adenylate-Cyclase- cAMP-Phosphodiesterase System

    • B. Lemmer, P.-H. Lang
    Pages 155-165

  17. Hypotensive Effect of β-Adrenoceptor Blockers

    • B. N. C. Prichard, F. Bompart
    Pages 166-191

  18. Effects of Antihypertensive Agents on Alpha and Beta Adrenoceptors

    • A. Daul, N. O’Hara, X. L. Wang, O.-E. Brodde
    Pages 193-207

  19. Mode of Action of Beta Blockers in Hypertension

    • J. M. Cruickshank
    Pages 208-230

  20. Back Matter

    Pages 231-233
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Keywords

About this book

This book reports on the current state of knowledge about adreno­ ceptors and their involvement in the pathogenesis and treatment of high blood pressure. This is a relatively recent and extremely excit­ ing addition to the field of hypertension research. The development of new analytical procedures, such as radio ligand-binding methods, has made it possible to identify and quantify the adrenoceptors in different tissues and in circulating blood cells. As a consequence, much new and valuable information has been obtained. An under­ standing of the role of the fJ-adrenoceptor-adenylatecyclase-cAMP system in hypertension is one such product of this new approach. Both review articles and new experimental and clinical data are included in this volume. New aspects of the distribution, identifica­ tion and regulation, and the chronopharmacology of adrenoceptors, as well as beta blockade, will be highlighted. The clinical contributions concern the normal regulation of the fJ­ adrenoceptor-adenylatecyclase-cAMP system, and how it is altered in hypertensives as a possible mechanism in the pathogenesis and maintenance of essential hypertension. With this knowledge it is be­ coming easier to explain the molecular and cellular action behind the familiar role of the sympathico-adrenergic system in the devel­ opment of hypertension and the mechanism of beta blockade. The vast majority of the data available in this field is confined to periph­ eral mechanisms, owing to the limited possibilities for investigating the central nervous system under clinical conditions.

Editors and Affiliations

  • Medizinische Poliklinik der Ludwig-Maximilians-Universität München, München 2, Federal Republic of Germany

    Martin Middeke, Heinrich Holzgreve

Bibliographic Information

  • Book Title: New Aspects in Hypertension Adrenoceptors

  • Book Subtitle: Symposium, November 1985, Munich

  • Editors: Martin Middeke, Heinrich Holzgreve

  • DOI: https://doi.org/10.1007/978-3-642-71418-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1986

  • Softcover ISBN: 978-3-642-71420-7Published: 06 December 2011

  • eBook ISBN: 978-3-642-71418-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 233

  • Topics: Cardiology, Pharmacology/Toxicology

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