Current Topics in Microbiology and Immunology

Human T-Cell Leukemia Virus

Editors: Vogt, P.K. (Ed.)

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characteristic features in common with the genome of other retroviruses: long terminal repeats (L TR), and coding regions for internal proteins (gag), for re­ verse transcriptase (pol), and for glycosylated virion surface proteins (env) , ar­ ranged in the sequence gag, pol, env from the 5' to the 3' end of the genome. However, the HTL V genome also contains some specific features not shared with all other retroviruses: the LTR regions are unusually long (745 base pairs, with 298 base pairs constituting the R region), but unlike the long L TRs of mouse mammary tumor viruses, they do not contain open reading frames. A stretch of noncoding sequences separates the gag and the pol genes. Most interestingly, the HTLV genome contains a region between the 3' end of the env gene and the L TR, called the pX region, that encompasses four open reading frames. Leukemic T cells freshly obtained from patients contain the HTL V provirus but usually do not express it. However, once established in culture, these cells produce viral proteins and release type C particles. Likewise, T cells infected and transformed by HTL V in vitro synthesize virus. Such producing cell lines have been widely used in seroepidemiological surveys and continue to be of importance for detailed studies of viral proteins and nucleic acids.

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Human T-Cell Leukemia/Lymphoma Viruses — An Introduction

    Pages 1-5

    Vogt, Peter K.

  • Isolation, Characterization, and Biological Effects of the First Human Retroviruses: The Human T-Lymphotropic Retrovirus Family

    Pages 7-31

    Robert-Guroff, Marjorie (et al.)

  • Human T-Cell Leukemia/Lymphoma Viruses (HTLV): A Unique Family of Pathogenic Retroviruses

    Pages 33-51

    Mitsuya, Hiroaki (et al.)

  • Epidemiology of Adult T-Cell Leukemia/Lymphoma in Japan

    Pages 53-66

    Tajima, Kazuo (et al.)

  • Human T-Cell Leukemia/Lymphoma Viruses: Clinical and Epidemiologic Features

    Pages 67-88

    Blattner, William A. (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-3-642-70113-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-3-642-70115-3
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Human T-Cell Leukemia Virus
Editors
  • P.K. Vogt
Series Title
Current Topics in Microbiology and Immunology
Series Volume
115
Copyright
1985
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-70113-9
DOI
10.1007/978-3-642-70113-9
Softcover ISBN
978-3-642-70115-3
Series ISSN
0070-217X
Edition Number
1
Number of Pages
X, 266
Topics