Interferons and Their Applications

1. Front Matter

   Pages I-XXIV

   PDF

2. Interferons and Their Applications: Past, Present, and Future

   • M. Krim

   Pages 1-22

3. Assay of Interferons

   • S. E. Grossberg, P. M. Jameson, J. J. Sedmak

   Pages 23-43

4. Evolution of Interferon Genes

   • D. Gillespie, E. Pequignot, W. A. Carter

   Pages 45-63

5. Comparative Analysis of Interferon Structural Genes

   • P. B. Sehgal, A. D. Sagar

   Pages 65-77

6. Comparative Structures of Mammalian Interferons

   • K. C. Zoon, R. Wetzel

   Pages 79-100

7. Regulatory Control of Interferon Synthesis and Action

   • H. Smith-Johannsen, Y-T. Hou, X-Y. Liu, Y-H. Tan

   Pages 101-135

8. Application of Recombinant DNA Technology to Expression of Human Interferon Genes

   • S. Panem

   Pages 137-151

9. The Molecular Mediators of Interferon Action

   • C. Baglioni

   Pages 153-168

10. The Cellular Effects of Interferon

    • J. L. Taylor, J. L. Sabran, S. E. Grossberg

    Pages 169-204

11. Interferon Induction by Viruses

    • P. I. Marcus

    Pages 205-232

12. Interferon Induction by Nucleic Acids: Structure-Activity Relationships

    • P. F. Torrence, E. De Clercq

    Pages 233-258

13. Production and Characterization of Human Leukocyte Interferon

    • N. O. Hill

    Pages 259-269

14. Lymphoblastoid Interferon: Production and Characterization

    • N. B. Finter, K. H. Fantes

    Pages 271-286

15. Fibroblast Interferons: Production and Characterization

    • V. G. Edy

    Pages 287-304

16. Immune Interferon

    • J. A. Georgiades, S. Baron, W. R. Fleischmann Jr., M. Langford, D. A. Weigent, G. J. Stanton

    Pages 305-337

17. Comparative Biologic Activities of Human Interferons

    • P. K. Weck, P. E. Came

    Pages 339-355

18. Manufacture and Safety of Interferons in Clinical Research

    • J. C. Petricciani, E. C. Esber, H. E. Hopps, A. Attallah

    Pages 357-370

19. Nonpolynucleotide Inducers of Interferon

    • D. A. Stringfellow

    Pages 371-383

20. Agents Which Modulate the Activity of Interferon

    • D. R. Strayer, W. A. Carter

    Pages 385-402

Today, the basic mood of researchers and clinical investigators, both at the center and on the periphery of interferon studies, is optimistic regarding the future of interferons as therapeutic substances. Many also feel these polypeptides will prove invaluable probes in unraveling certain fundamental biochemical processes which control the life cycle and developmental pattern of many human cells. In contrast, only a year or two ago, this optimism had given way to an attitude almost of disenchantment as public and scientific expectations were raised steeply, then rapidly waned, as it turns out, prematurely. Both the mUltiple actions of interferons (a virtual cascade of biochemical reactions may be induced, as documented herein) and the high visibility of interferon research provided by the millions of dollars invested both by national health agencies and by multinational pharmaceutical companies, contributed to an upsweep in public attention to drug development probably unprecedented in this century. Virtually every oncologist, it would seem, was plagued by requests for the experimental agent, although they already had therapies of more proven value. As recently as 1980, even though interferon had achieved success against certain cancers and certain viral diseases, the variability in clinical results was seemingly ever present and little evidence emerged to suggest interferons could cure advanced diseases. Why then the resurgence of an optimistic mood? There are almost always many elements which contribute to happiness, and this is certainly true of the broad frontier of interferon and its place in biochemical research and treatment.

• Histamin
• Hormone
• Insulin
• Prostaglandin
• Vitamin A
• antibody
• antigen
• cancer
• chromatography
• hepatitis
• interferon
• pharmacokinetics
• pharmacology
• research
• toxicology

• HEM Research Inc., Rockville, USA

  Paul E. Came

• Clinical Research, Department of Oncology, Orlowitz Cancer Institute, Philadelphia, USA

  William A. Carter

• Department of Hematology and Oncology, Hahnemann University of Health Sciences, Philadelphia, USA

  William A. Carter

Policies and ethics