Handbook of Experimental Pharmacology

Cardiac Glycosides

Part II: Pharmacokinetics and Clinical Pharmacology

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The pharmacokinetics of digitalis glycosides have been the subject of extensive re­ view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com­ pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm­ LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in­ dicate that the elimination half-life of strophanthin is prolonged in renal failure.

Table of contents (15 chapters)

Table of contents (15 chapters)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-68166-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.99
price for USA in USD
  • ISBN 978-3-642-68168-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cardiac Glycosides
Book Subtitle
Part II: Pharmacokinetics and Clinical Pharmacology
Series Title
Handbook of Experimental Pharmacology
Series Volume
56 / 2
Copyright
1981
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-68166-0
DOI
10.1007/978-3-642-68166-0
Softcover ISBN
978-3-642-68168-4
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XXI, 394
Topics