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Current Topics in Microbiology and Immunology

Initiation Signals in Viral Gene Expression

Editors: Shatkin, A. J. (Ed.)

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About this book

Elucidating Mechanisms of Eukaryotic Genetic Expression by Studying Animal Viruses AARON 1. SHATIGN* Eukaryotic genetic expression is carefully regulated. Normal cell growth and division, tis­ sue differentiation, and organism development all depend on a strictly ordered progres­ sion of specific events. Perturbation of the control of these processes, for example by ex­ posure to harmful chemicals or infection with viruses leads to aberrant forms of meta­ bolism, often resulting in malignancies and cell death. One of the most challenging problems in biology is to derme at the molecular level the mechanisms that govern gene function in higher organisms, including ultimately man. This goal serves to unify the diverse efforts of many investigators, whether studying the precise patterns of embryo­ genesis, the loss of control that occurs during neoplastic growth or the redirection of biosynthetic pathways in virus-infected cells. Recently there has been remarkable and exciting progress toward understanding the molecular biology of eukaryotic expression. Much of this rapidly increasing new infor­ mation has come from studies of animal virus systems. Just as investigations of the relatively simple, rapidly assayed, and easily manipulated bacteriophages lead to basic discoveries about prokaryotic cells, analyses of animal viruses and their interactions with host cells have provided fundamental information about how eukaryotic nucleic acids are organized for regulated replication, transcription, and translation. For example, the small genome of SV , like cellular DNA in chromatin, is associated with histones to 40 form nucleosomal arrays (Griffin 1975).

Table of contents (7 chapters)

Table of contents (7 chapters)
  • Introduction Elucidating Mechanisms of Eukaryotic Genetic Expression by Studying Animal Viruses

    Pages 1-4

    Shatkin, Aaron J.

  • Regulation of Viral Transcription and DNA Replication by the SV40 Large T Antigen

    Pages 5-24

    Tjian, Robert

  • Transcriptional Control Regions: Nucleotide Sequence Requirements for Initiation by RNA Polymerase II and III

    Pages 25-46

    Shenk, Thomas

  • Splicing and the Regulation of Viral Gene Expression

    Pages 47-79

    Flint, S. J.

  • Mechanism of mRNA Recognition by Eukaryotic Ribosomes During Initiation of Protein Synthesis

    Pages 81-123

    Kozak, Marilyn

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-3-642-68123-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Initiation Signals in Viral Gene Expression
Editors
  • A. J. Shatkin
Series Title
Current Topics in Microbiology and Immunology
Series Volume
93
Copyright
1981
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-68123-3
DOI
10.1007/978-3-642-68123-3
Softcover ISBN
978-3-642-68125-7
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VI, 214
Topics

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