Heme and Hemoproteins

1. Front Matter

   Pages I-XVII

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2. The Biosynthesis and Degradation of Heme

   • George H. Tait

   Pages 1-48

3. Induction of Hepatic Hemoproteins

   • K. W. Bock, H. Remmer

   Pages 49-80

4. Inhibition of Liver Hemoprotein Synthesis

   • Thomas R. Tephly

   Pages 81-94

5. Loss of Liver Cytochrome P-450 Caused by Chemicals

   • F. De Matteis

   Pages 95-127

6. Hepatic Porphyrias

   • F. De Matteis

   Pages 129-155

7. Porphyria Caused by Hexachlorobenzene and Other Polyhalogenated Aromatic Hydrocarbons

   • G. H. Elder

   Pages 157-200

8. The Effect of Chemicals on Hepatic Heme Biosynthesis

   • Gerald S. Marks

   Pages 201-237

9. Pharmacogenetics in the Field of Heme Metabolism: Drug Sensitivity in Hereditary Hepatic Porphyria

   • J. Douglas Maxwell, Urs A. Meyer

   Pages 239-254

10. The Influence of Hormonal and Nutritional Factors on the Regulation of Liver Heme Biosynthesis

    • D. P. Tschudy

    Pages 255-271

11. Effects of Drugs on Bilirubin Metabolism

    • H. L. Rayner, B. A. Schacter, L. G. Israels

    Pages 273-332

12. Toxic Effects of Lead, with Particular Reference to Porphyrin and Heme Metabolism

    • Shigeru Sassa

    Pages 333-371

13. Back Matter

    Pages 373-452

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The study of the biological effects of foreign chemicals (whether therapeutic drugs or chemicals present at work or in the environment) interests the biologist from a number of different and complementary viewpoints. Apart from the more obvious pharmacological and toxicological interest, the experimentalist often uses foreign chemicals to produce in experimental animals disease states similar to naturally occurring diseases, so that their pathogenetic mechanisms and therapy can be studied under controlled conditions. In addition - as Claude Bernard pointed out over a century ago - foreign chemicals can be employed as instruments to analyze the most delicate vital processes; much can be learned about the physiological processes themselves by a careful study of the mechanisms by which these are altered by chemicals. The field of heme and hemoproteins offers an example of the interplay of these different approaches. Their metabolism can be altered by therapeutic drugs and other foreign chemicals and this results in a variety of biological responses that transcend the boundaries of pharmacology into the confines of clinical medi­ cine, genetics, toxicology, biochemistry and physiology. In this book a multidisciplinary approach to the study of heme metabolism is presented including the effect of chemicals on heme metabolism in patients, the results of experimental work in the whole animal, as well as in vitro studies.

• Arzneimittelnebenwirkung
• Bilirubin
• Biosynthese
• Eiweiss
• Häm
• Leber
• Pharmakologie
• Porphyrie
• therapy

• Medical Research Council Labs., MRC Toxicology Unit, Carshalton, Surrey, Great Britain

  Francesco Matteis, W. Norman Aldridge

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