Antineoplastic and Immunosuppressive Agents

1. Front Matter

   Pages I-XXXII

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2. Alkylating Agents

   1. Chemistry of Alkylation

      • Charles C. Price

      Pages 1-5

   2. Molecular Biology of Alkylation: An Overview

      • David B. Ludlum

      Pages 6-17

   3. Mechanism of Action of 2-Chloroethylamine Derivatives, Sulfur Mustards, Epoxides, and Aziridines

      • T. A. Connors

      Pages 18-34

   4. Mechanism of Action of Methanesulfonates

      • Brian W. Fox

      Pages 35-46

   5. Mechanism of Action of Mitomycins

      • H. Kersten

      Pages 47-64

   6. Mechanism of Action of Nitrosoureas

      • Glynn P. Wheeler

      Pages 65-84

3. Hormones

   1. Mechanism of Action of Glucocorticoids

      • Fred Rosen, Richard J. Milholland

      Pages 85-103

   2. Mechanisms of Action of Estrogens

      • Russell Hilf, James L. Wittliff

      Pages 104-138

   3. Mechanism of Action of Androgens

      • Russell Hilf

      Pages 139-157

   4. Mechanism of Action of Progesterone

      • Bert W. O’Malley, Charles A. Strott

      Pages 158-169

   5. Pharmacology and Clinical Utility of Hormones in Hormone Related Neoplasms

      • Thomas L. Dao

      Pages 170-192

4. Antimetabolites

   1. Fluorinated Pyrimidines and Their Nucleosides

      • Charles Heidelberger

      Pages 193-231

   2. Arabinosylcytosine

      • William A. Creasey

      Pages 232-256

   3. Clinical Pharmacology of Arabinosylcytosine

      • D. H. W. Ho, E. J. Freireich

      Pages 257-271

   4. Halogenated Pyrimidine Deoxyribonucleosides

      • William H. Prusoff, Barry Goz

      Pages 272-347

   5. Azapyrimidine Nucleosides

      • J. Škoda

      Pages 348-372

   6. Showdomycin, 5-Hydroxyuridine, and 5-Aminouridine

      • D. W. Visser

      Pages 373-383

   7. 6-Thiopurines

      • A. R. P. Paterson, D. M. Tidd

      Pages 384-403

   8. Azathioprine

      • Gertrude B. Elion, George H. Hitchings

      Pages 404-425

Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a single volume the entire field of drugs employed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons to publish the material in two parts, although the plan of the work constitutes, at least in the editors' view, a single integrated treatment of this research area. A number of factors have contributed to the continuous expansion of research in the areas of cancer chemotherapy and immunosuppression. Active compounds have been emerging at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories through­ out the world. At the molecular level, knowledge of the modes of action of established agents has continued to expand, and has permitted rational drug design to play a significantly greater role in a process which, in its early years, depended almost completely upon empirical and fortuitous observations.

• cancer
• chemotherapy
• drug
• immunosuppression
• pharmacology
• research

• Department of Pharmacology, Yale University School of Medicine, New Haven, USA

  Alan C. Sartorelli

• Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, USA

  David G. Johns

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