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Current Topics in Microbiology and Immunology

Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung

Authors: Arber, W., Braun, W., Haas, R., Henle, W., Hofschneider, P.H., Jerne, N.K., Koldovský, P., Koprowski, H., Maaløe, O., Rott, R., Schweiger, H.G., Sela, M., Svru?ek, L., Vogt, P.K., Wecker, E.

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The expression of many bacterial genes adapts itself in an almost in­ stantaneous and reversible way to specific environmental changes. More specifically, the concentration of a number of metabolites, a function of the amounts of enzymes involved in their synthesis or degradation, in turn retroacts on the rate of synthesis of these enzymes. The genetic bases for this regulation were established by JACOB and MONOD (1961). These authors also showed how the known elements of these regulatory mechanisms could be connected into a wide variety of circuits endowed with any desired degree of stability, in order to account for essentially irreversible processes like differentiation (MONOD and JACOB, 1961). The general principles used by JACOB and MONOD in their study of negative regulation were extended to positive regulation by ENGLESBERG et al. (1965). An independent approach permitted the discovery of positive controls in temperate bacteriophages (see below, III). Each control operation is mediated by a pair of complementary genetic elements (hereafter called "control cell"): a control gene which produces a l control (or regulator) protein and a control site which is the target for the regulator protein. Negative control means that the control protein (repressor) prevents gene expression. One deals with positive control when the control protein (activator) is necessary for this expression. It has become apparent that, as initially postulated by JACOB and MONOD, control of gene expression operates, at least to a large extent, at the transcriptional level.

Table of contents (4 chapters)

Table of contents (4 chapters)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-642-65241-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-65243-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung
Authors
Series Title
Current Topics in Microbiology and Immunology
Series Volume
56
Copyright
1971
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin · Heidelberg
eBook ISBN
978-3-642-65241-7
DOI
10.1007/978-3-642-65241-7
Softcover ISBN
978-3-642-65243-1
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IV, 226
Topics

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