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Current Topics in Microbiology and Immunology

Chromosomal Translocations and Oncogenic Transcription Factors

Editors: Rauscher, Frank J. III, Vogt, Peter K. (Eds.)

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About this book

Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Disruption of a Homolog of Trithorax by 11q23 Translocations: Leukemogenic and Transcriptional Implications

    Pages 1-23

    Waring, P. M. (et al.)

  • E2A-Pbx1 Induces Growth, Blocks Differentiation, and Interacts with Other Homeodomain Proteins Regulating Normal Differentiation

    Pages 25-43

    Kamps, M. P.

  • E2A-HLF Chimeric Transcription Factors in Pro-B Cell Acute Lymphoblastic Leukemia

    Pages 45-53

    Look, A. T.

  • Transcription Factors of the bHLH and LIM Families: Synergistic Mediators of T Cell Acute Leukemia?

    Pages 55-65

    Baer, R. (et al.)

  • The TEL Gene Contributes to the Pathogenesis of Myeloid and Lymphoid Leukemias by Diverse Molecular Genetic Mechanisms

    Pages 67-79

    Golub, T. R. (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-60479-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-3-642-64424-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chromosomal Translocations and Oncogenic Transcription Factors
Editors
  • Frank J. III Rauscher
  • Peter K. Vogt
Series Title
Current Topics in Microbiology and Immunology
Series Volume
220
Copyright
1997
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-60479-9
DOI
10.1007/978-3-642-60479-9
Softcover ISBN
978-3-642-64424-5
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XI, 166
Topics