Skip to main content
SpringerLink
Log in

Risk and Progression Factors in Carcinogenesis

  • Conference proceedings
  • © 1997

Overview

Editors:
  1. H. K. Müller-Hermelink

    1. Pathologisches Institut, der Universität Würzburg, Würzburg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. H.-G. Neumann

    1. Institut für Pharmakologie und Toxikologie, der Universität Würzburg, Würzburg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. W. Dekant

    1. Institut für Pharmakologie und Toxikologie, der Universität Würzburg, Würzburg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 143)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (26 papers)

  1. Front Matter

    Pages I-XII
    Download chapter PDF

  2. Interaction of Carcinogens with Cellular DNA

    1. Induction of Frameshift Mutations at Hotspot Sequences by Carcinogen Adducts

      • D. Burnouf, M. Bichara, C. Dhalluin, A. Garcia, R. Janel-Bintz, N. Koffel-Schwartz et al.
      Pages 1-20

    2. Oxidative DNA Damage Induced by Dioxetanes, Photosensitizing Ketones, and Photo-Fenton Reagents

      • W. Adam, S. Andler, D. Ballmaier, S. Emmert, B. Epe, G. Grimm et al.
      Pages 21-34

    3. Oxidative DNA Damage Profiles in Mammalian Cells

      • D. Ballmaier, M. Pflaum, C. Kielbassa, B. Epe
      Pages 35-47

    4. Chemical Mechanisms of Formation of DNA-Carcinogen Adducts, Elucidation of Potential of Adducts for Mutagenicity, and Mechanisms of Polymerase Fidelity and Mutation in the Presence of Adducts

      • F. P. Guengerich, M.-S. Kim, M. Müller, L. G. Lowe
      Pages 49-63

    5. Assessment of the Tumor-Initiating Potential of α,β-Unsaturated Carbonyl Compounds by 32P Postlabeling Quantification of DNA Adducts In Vivo

      • E. Eder, Budiawan, D. Schuler, M. Otteneder
      Pages 65-75

    6. Glutathione-Dependent Bioactivation and Renal Toxicity of Xenobiotics

      • W. Dekant
      Pages 77-87

    7. UItraviolet-Induced Photolesions: Repair and Mutagenesis

      • L. H. F. Mullenders, A. van Hoffen, M. P. G. Vreeswijk, H.-J. Ruven, H. Vrieling, A. A. van Zeeland
      Pages 89-99

    8. Psoralen Photobiology: The Relationship Between DNA Damage, Chromatin Structure, Transcription, and Immunogenic Effects

      • F. P. Gasparro, A. Felli, I. M. Schmitt
      Pages 101-127

  3. Analysis of Cellular Alterations and Growth Dysregulation in Cancer Cells

    1. Cellular Stress Response: Stress Proteins — Physiology and Implications for Cancer

      • R. Benndorf, H. Bielka
      Pages 129-144

    2. Two-Dimensional Polyacrylamide Gel Electrophoresis of Cancer-Associated Proteins

      • P. J. Wirth, L.-di Luo, T. Hoang, T. Benjamin
      Pages 145-160

    3. Mechanisms Leading to the Expression of Recessive Alleles: The Use of Polymorphic Microsatellites and Whole-Chromosome Painting Probes to Analyze Mouse Tumors, Mutants, and Micronuclei

      • W. J. Caspary, H. Stopper, J. C. Hozier, M. C. Liechty, L. M. Davis
      Pages 161-182

    4. Formation of Micronuclei and Inhibition of Topoisomerase II in the Comet Assay in Mammalian Cells with Altered DNA Methylation

      • H. Stopper, I. Eckert, P. Wagener, W. A. Schulz
      Pages 183-193

    5. Poly(ADP-Ribosyl)ation and Nuclear Matrix/Intermediate Filament Proteins in Renal Carcinogenesis

      • S. Vamvakas, H. Richter, D. Bittner
      Pages 195-208

    6. Genotoxic and Chronic Toxic Effects in the Carcinogenicity of Aromatic Amines

      • A. Bitsch, J. Fecher, M. Jost, P.-C. Klöhn, H.-G. Neumann
      Pages 209-223

    7. Analysis of Genetic Factors and Molecular Mechanisms in the Development of Hereditary and Carcinogen-Induced Tumors of Xiphophorus

      • A. Schartl, M. Pagany, M. Engler, M. Schartl
      Pages 225-235

    8. The Role of Raf Kinases in Development and Growth of Tumors

      • U. Naumann, I. Eisenmann-Tappe, U. R. Rapp
      Pages 237-244

    9. Apoptosis Regulation by Raf, Bcl-2, and R-Ras

      • J. Troppmair, U. R. Rapp
      Pages 245-249

    10. New Cell Cycle-Regulated Genes in the Yeast Saccharomyces cerevisiae

      • T. Schuster, C. Price, W. Rossoll, B. Kovacech
      Pages 251-261

    11. The Role of Workhorse Protein Kinases in Coordinating DNA Metabolism and Cell Growth

      • E. Christenson, A. J. DeMaggio, M. F. Hoekstra
      Pages 263-274
Back to top

Keywords

About this book

Cellular transformation and carcinogenesis are considered a multistep process starting with DNA lesions and progressing through loss of cellular growth control and increase invasive and metastatic properties. This book focuses on the demonstration of important steps in carcinogenesis, ranging from chemical interaction of carcinogens with cellular DNA in experimental tumors and cell lines to the analysis of selected human tumors. Special importance is given to the clarification of mechanisms of DNA lesions caused by chemical carcinogens and UV irradiation. Leading scientists describe in review articles the actual state of the art in their specific fields. The reader is informed of trends and scientific approaches to the recognition of pathogenetic mechanisms and factors in malignant tumors.

Editors and Affiliations

  • Pathologisches Institut, der Universität Würzburg, Würzburg, Germany

    H. K. Müller-Hermelink

  • Institut für Pharmakologie und Toxikologie, der Universität Würzburg, Würzburg, Germany

    H.-G. Neumann, W. Dekant

Bibliographic Information

  • Book Title: Risk and Progression Factors in Carcinogenesis

  • Editors: H. K. Müller-Hermelink, H.-G. Neumann, W. Dekant

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-60393-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1997

  • Softcover ISBN: 978-3-642-64385-9Published: 21 January 2012

  • eBook ISBN: 978-3-642-60393-8Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XII, 394

  • Topics: Oncology

Publish with us

Policies and ethics

Back to top

Search

Navigation