Signaling Through the Cell Matrix

1. Front Matter

   Pages I-X

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2. Topological Constraints Carry Signaling from the Cell Matrix to the Genome

   • Alvaro Macieira-Coelho

   Pages 1-19

3. The Transmission of Contractility Through Cell Adhesion

   • Kyoko Imanaka-Yoshida

   Pages 21-35

4. Role of Focal Adhesion Kinase in Signaling by the Extracellular Matrix

   • Ji-He Zhao, Jun-Lin Guan

   Pages 37-55

5. Interaction Between Cells and Extracellular Matrix: Signaling by Integrins and the Elastin-Laminin Receptor

   • J. Labat-Robert, L. Robert

   Pages 57-70

6. Regulation of Gene Expression by Changes in Cell Adhesion

   • Takejiro Kuzumaki

   Pages 71-87

7. Expression of Liver Specific-Genes in Hepatocytes Cultured in Collagen Gel Matrix

   • Maria José Gómez-Lechón, Ramiro Jover, Teresa Donato, Xavier Ponsoda, José V. Castell

   Pages 89-104

8. Collagen Type I: A Substrate and a Signal for Invasion

   • Leen Van Hoorde, Elisabeth Van Aken, Marc Mareel

   Pages 105-134

9. Back Matter

   Pages 135-136

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This book covers a hot subject in cell biology; i.e. how the cell environment sends messages to the cell, regulates gene expression, and modulates the cell phenotype. For a long time the extracellular matrix was believed to have only a supporting role for cell attachement. However, it became apparent that the matrix participates actively in cell metabolism. The experiments that led to this conclusion are described in this volume. Progressively, molecules have been identified that transmit this signaling at the cell-matrix interface. Their identity and mechanism of action are also illustrated in this book. Finally, it explains the role the cell-matrix relationship plays in the regulation of cell proliferation, cell differentiation, and the expression of malignancy.

• Activation
• cancer
• cell
• cell biology
• cell differentiation
• cellular differentiation
• enzyme
• gene
• gene expression
• genome
• liver
• metabolism
• regulation
• topology
• transcription

• University of Paris VI, Versailles, France

  Alvaro Macieira-Coelho

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