Current Topics in Microbiology and Immunology

Origin and Evolution of the Vertebrate Immune System

Editors: Du Pasquier, L., Litman, G.W. (Eds.)

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The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop­ ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte­ brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or­ igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo­ lecular contexts in which the mechanism was introduced.

Table of contents (14 chapters)

Table of contents (14 chapters)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-642-59674-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.99
price for USA in USD
  • ISBN 978-3-642-64078-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Origin and Evolution of the Vertebrate Immune System
Editors
  • L. Du Pasquier
  • G.W. Litman
Series Title
Current Topics in Microbiology and Immunology
Series Volume
248
Copyright
2000
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-59674-2
DOI
10.1007/978-3-642-59674-2
Softcover ISBN
978-3-642-64078-0
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IX, 326
Topics