Handbook of Experimental Pharmacology

The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems

Editors: Kenakin, T., Angus, J. A. (Eds.)

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About this book

This, the 148th volume of the Handbook of Experimental Pharmacology series, focuses on the very core of pharmacology, namely receptor theory. It is fitting that the originator of receptor pharmacology, A. J. CLARK, authored the fourth volume of this series 63 years ago. In that volume CLARK further developed his version of receptor theory first described four years earlier in his classic book The Mode of Action of Drugs. An examination of the topics covered in volume 4 reveals a striking similarity to the topics covered in this present volume; pharmacologists today are still as interested in unlocking the secrets of dose-response relationships to reveal the biological and che­ mical basis of drug action as they were over half a century ago. Sections in that 1937 volume such as "Curves relating exposure to drugs with biological effects" and "Implications of monomolecular theory" show Clark's keen insight into the essential questions that required answers to move pharma­ cology forward. With the advent of molecular biological cloning of human receptors has come a transformation of receptor pharmacology. Thus the expression of human receptors into surrogate host cells helped unlock secrets of receptor mechanisms and stimulus-transduction pathways. To a large extent, this elim­ inates the leap of faith required to apply receptor activity of drugs tested on animal receptor systems to the human therapeutic arena. However, a new leap of faith concerning the veracity of the effects found in recombinant systems with respect to natural ones is now required.

Table of contents (16 chapters)

Table of contents (16 chapters)

Buy this book

eBook $84.99
price for USA in USD
  • ISBN 978-3-642-57081-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.99
price for USA in USD
  • ISBN 978-3-642-63028-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems
Editors
  • T. Kenakin
  • J. A. Angus
Series Title
Handbook of Experimental Pharmacology
Series Volume
148
Copyright
2000
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-57081-0
DOI
10.1007/978-3-642-57081-0
Softcover ISBN
978-3-642-63028-6
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XX, 448
Number of Illustrations
131 b/w illustrations, 1 illustrations in colour
Topics