Overview
- Covers wide range of different membrane transporters
- Links 3D structure to function
- Written by international renowned experts
Part of the book series: Springer Series in Biophysics (BIOPHYSICS, volume 17)
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Table of contents (11 chapters)
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Front Matter
Keywords
About this book
This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, “a molecular movie”. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics.
Editors and Affiliations
Bibliographic Information
Book Title: Membrane Transport Mechanism
Book Subtitle: 3D Structure and Beyond
Editors: Reinhard Krämer, Christine Ziegler
Series Title: Springer Series in Biophysics
DOI: https://doi.org/10.1007/978-3-642-53839-1
Publisher: Springer Berlin, Heidelberg
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2014
Hardcover ISBN: 978-3-642-53838-4Published: 27 March 2014
Softcover ISBN: 978-3-662-52305-6Published: 23 August 2016
eBook ISBN: 978-3-642-53839-1Published: 13 March 2014
Series ISSN: 0932-2353
Series E-ISSN: 1868-2561
Edition Number: 1
Number of Pages: XII, 272
Number of Illustrations: 9 b/w illustrations, 56 illustrations in colour
Topics: Membrane Biology, Protein Structure, Biological and Medical Physics, Biophysics, Crystallography and Scattering Methods, Computational Biology/Bioinformatics