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Springer Lab Manuals

RNP Particles, Splicing and Autoimmune Diseases

Editors: Schenkel, Johannes (Ed.)

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  • A practical tool for anyone working at the lab bench
  • Easy to follow step-by-step protocols
  • Background information and full practical details
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eBook $84.99
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  • ISBN 978-3-642-80356-7
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Softcover $109.00
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  • ISBN 978-3-642-48975-4
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About this book

The maturation of the precursors of mRNA to a functional transcript in eukaryotic cells is a complex, multistep process. It includes the formation of RNP complexes and the splicing procedure. Also, the presence of snRNA packaged as snRNP particles plays an important role in this process. In addition, snRNPs are involved in various autoimmune diseases in which autoantibodies are directed against components of these particles.
Relevant techniques to investigate RNA processing, splicing, protein-RNA complex formation and protein-RNA interactions as well as the use of autoantibodies in basic and clinical research are presented in this manual.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Isolation and Immunochemical Characterization of hnRNP Particles

    Pages 1-28

    Jung, Frank (et al.)

  • The InRNP Particle — A Naturally Assembled Complex of Pre-mRNA and Splicing Factors

    Pages 29-47

    Sperling, Ruth (et al.)

  • Intrinsic Fluorescence Techniques for Studies on Protein-Protein and Protein-RNA Interactions in RNP Particles

    Pages 48-71

    Greulich, Karl Otto

  • Procedures for Three-Dimensional Reconstruction from Thin Sections with Electron Tomography

    Pages 72-94

    Skoglund, Ulf (et al.)

  • Purification and Electron Microscopy of Spliceosomal snRNPs

    Pages 95-140

    Kastner, Berthold

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-3-642-80356-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-3-642-48975-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
RNP Particles, Splicing and Autoimmune Diseases
Editors
  • Johannes Schenkel
Series Title
Springer Lab Manuals
Copyright
1998
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-80356-7
DOI
10.1007/978-3-642-80356-7
Softcover ISBN
978-3-642-48975-4
Edition Number
1
Number of Pages
X, 225
Number of Illustrations
90 b/w illustrations
Topics