Biology of the Mouse Histocompatibility-2 Complex

1. Front Matter

   Pages i-xii

   PDF

2. Introduction

   1. Front Matter

      Pages 1-1

      PDF

   2. History

      • Jan Klein

      Pages 3-15

   3. The Mouse and Its Forms

      • Jan Klein

      Pages 16-39

3. Peripheral Regions of the H-2 Complex

   1. Front Matter

      Pages 41-41

      PDF

   2. Serology

      1. Introduction to Serological Analysis

         • Jan Klein

         Pages 45-66

      2. Methods of Serological H-2 Typing

         • Jan Klein

         Pages 67-80

      3. Current Status of H-2 Serology

         • Jan Klein

         Pages 81-127

   3. Histocompatibility

      1. Introduction to Histocompatibility

         • Jan Klein

         Pages 131-140

      2. Methods of Histocompatibility Testing

         • Jan Klein

         Pages 141-150

      3. Histocompatibility System of the Mouse

         • Jan Klein

         Pages 151-177

   4. Genetics

      1. Principles of Genetic Analysis

         • Jan Klein

         Pages 181-191

      2. Recombination and Mutation in the <i>H-2</i> Complex

         • Jan Klein

         Pages 192-230

      3. Genetics of <i>H-2</i>-Linked Loci

         • Jan Klein

         Pages 231-283

      4. Population Genetics of the <i>t</i> and <i>H-2</i> Systems

         • Jan Klein

         Pages 284-304

      5. The <i>H-2</i> Complex and Somatic Cell Genetics

         • Jan Klein

         Pages 305-326

   5. Biochemistry

      1. Cellular and Subcellular Distribution of H-2 Antigens

         • Jan Klein

         Pages 329-350

      2. Biochemical Aspects of H-2 Antigens

         • Jan Klein

         Pages 351-383

4. Central Regions of the H-2 Complex

   1. Front Matter

      Pages 385-385

      PDF

   2. I-region associated traits

      1. Genetic Control of Virus Susceptibility

         • Jan Klein

         Pages 389-410

Somewhere I heard a story of a bridge and a painter. The bridge was enormous and was made all of metal, and the painter's job was to keep it from rusting. He would start at one end and slowly proceed, day by day, month by month, toward the other end, painting the bridge. But no sooner would he finish with the painting than the bridge would begin to rust again. The rust, too, would start at one end and slowly proceed toward the other end, systematically destroying the painter's endeavor. And so the painter would return to where he had started, and begin painting again, slowly proceeding toward the other end of the bridge, always just one step ahead of the rust. And if the story is true, the painter might still be painting that bridge-a modern Sisyphus! During the writing of this book, the story of the painter and his bridge kept coming to mind. The field the book covers has been developing so rapidly that, like the painter, I too had to return to where I had started and fight the rust of obsolescence. But unlike the painter, I had a deadline to meet, which constituted a point of no return. And so, sending off this manuscript, I have no choice but to watch the fruits of my endeavor be overtaken by the rust.

• Histokompatibilität
• Maus
• biochemistry
• biology
• cell
• chemistry
• genetics
• metals
• virus

• Department of Microbiology, Southwestern Medical School, The University of Texas, Dallas, USA

  Jan Klein

Policies and ethics