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Research and Perspectives in Alzheimer's Disease

Proteopathic Seeds and Neurodegenerative Diseases

Editors: Jucker, Mathias, Christen, Yves (Eds.)

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  • With contributions from nobel laureats Eric Kandel and Stanley Prusiner
  • Latest research on prion diseases
  • Presents developing therapies ​
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  • ISBN 978-3-642-35491-5
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About this book

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer´s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ​

Table of contents (11 chapters)

Table of contents (11 chapters)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-3-642-35491-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-642-35490-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-3-642-44696-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Proteopathic Seeds and Neurodegenerative Diseases
Editors
  • Mathias Jucker
  • Yves Christen
Series Title
Research and Perspectives in Alzheimer's Disease
Copyright
2013
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-35491-5
DOI
10.1007/978-3-642-35491-5
Hardcover ISBN
978-3-642-35490-8
Softcover ISBN
978-3-642-44696-2
Series ISSN
0945-6066
Edition Number
1
Number of Pages
XII, 156
Topics

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