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Springer Theses

Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

Authors: Duffy, Colm

  • Nominated by University College Dublin as an outstanding PhD thesis
  • Author describes for the first time the synthesis of an enantiomerically pure form of pyridine-containing LXA4
  • Description of an excellent route to a thiophene-containing LXA4 analogue
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-24632-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
  • ISBN 978-3-642-24631-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA in USD
  • ISBN 978-3-642-43892-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

Table of contents (6 chapters)

  • Introduction

    Duffy, Colm

    Pages 1-9

  • Recent Advances in the Chemistry and Biology of Stable Synthetic Lipoxin Analogues

    Duffy, Colm

    Pages 11-39

  • Synthesis of Heck Coupling Partner for the Preparation of Heteroaromatic Lipoxin A4 Analogues

    Duffy, Colm

    Pages 41-53

  • Synthesis and Biological Evaluation of Pyridine-Containing Lipoxin A4 Analogues

    Duffy, Colm

    Pages 55-82

  • Thiophene-Containing Lipoxin A4 Analogues: Synthesis and Their Effect on the Production of Key Cytokines

    Duffy, Colm

    Pages 83-108

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-24632-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
  • ISBN 978-3-642-24631-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA in USD
  • ISBN 978-3-642-43892-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Heteroaromatic Lipoxin A4 Analogues
Book Subtitle
Synthesis and Biological Evaluation
Authors
Series Title
Springer Theses
Copyright
2012
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-24632-6
DOI
10.1007/978-3-642-24632-6
Hardcover ISBN
978-3-642-24631-9
Softcover ISBN
978-3-642-43892-9
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXII, 130
Topics