Skip to main content
  • Book
  • © 2012

Notch Regulation of the Immune System

Editors:

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 360)

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (9 chapters)

  1. Front Matter

    Pages i-xi
  2. The Notch Pathway in Hematopoietic Stem Cells

    • Anna Bigas, Teresa D’Altri, Lluis Espinosa
    Pages 1-18
  3. Notch Receptor-Ligand Interactions During T Cell Development, a Ligand Endocytosis-Driven Mechanism

    • Divya K. Shah, Juan Carlos Zúñiga-Pflücker
    Pages 19-46
  4. Notch1 and IL-7 Receptor Signalling in Early T-cell Development and Leukaemia

    • Sara González-García, Marina García-Peydró, Juan Alcain, María L. Toribio
    Pages 47-73
  5. Notch Signaling During Human T cell Development

    • Tom Taghon, Els Waegemans, Inge Van de Walle
    Pages 75-97
  6. Canonical and Non-Canonical Notch Signaling in CD4+ T Cells

    • Lisa M. Minter, Barbara A. Osborne
    Pages 99-114
  7. The Role of Notch in the Differentiation of CD4+ T Helper Cells

    • Floriane Auderset, Manuel Coutaz, Fabienne Tacchini-Cottier
    Pages 115-134
  8. Notch Signaling in Alloreactive T Cell Immunity

    • Jooho Chung, Ivan Maillard
    Pages 135-150
  9. Notch2 and Immune Function

    • Mamiko Sakata-Yanagimoto, Shigeru Chiba
    Pages 151-161
  10. Recent Advances on NOTCH Signaling in T-ALL

    • Gannie Tzoneva, Adolfo A. Ferrando
    Pages 163-182
  11. Back Matter

    Pages 183-184

About this book

Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system.  This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.

Editors and Affiliations

  • , EPFL SV ISREC UPRAD, University of Lausanne, Lausanne, Switzerland

    Freddy Radtke

Bibliographic Information

  • Book Title: Notch Regulation of the Immune System

  • Editors: Freddy Radtke

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-24294-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2012

  • Hardcover ISBN: 978-3-642-24293-9Published: 07 September 2012

  • Softcover ISBN: 978-3-642-43408-2Published: 15 October 2014

  • eBook ISBN: 978-3-642-24294-6Published: 13 September 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XII, 184

  • Topics: Immunology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access