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Springer Theses

Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane

Authors: Guseva, Ksenia

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  • Nominated as an outstanding contribution by the University of Aberdeen
  • Contains essential new results on the statistical mechanics and dynamics of macromolecular assembly
  • Yields important conclusions and predictions for biological membranes
  • Work done in close cooperations with biologists studying membrane proteins
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About this book

With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.

Table of contents (5 chapters)

Table of contents (5 chapters)

Buy this book

eBook $89.00
price for USA in USD
  • ISBN 978-3-642-23988-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.99
price for USA in USD
Softcover $119.99
price for USA in USD
Rent the eBook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane
Authors
Series Title
Springer Theses
Copyright
2012
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-23988-5
DOI
10.1007/978-3-642-23988-5
Hardcover ISBN
978-3-642-23987-8
Softcover ISBN
978-3-642-26994-3
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XII, 80
Topics

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