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Current Topics in Microbiology and Immunology

Mucosal Vaccines

Modern Concepts, Strategies, and Challenges

Editors: Kozlowski, Pamela A. (Ed.)

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About this book

This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.

Reviews

From the reviews:

“This is a neat little book giving a good overview of the world of mucosal vaccines. … Each chapter has a comprehensive list of references and some pleasing figures … . I would recommend that any institution working on vaccine development should invest in a copy. It would be particularly useful for a first year PhD student embarking on a vaccine development project.” (Helen Ambrose, Microbiology Today, November, 2012)

Table of contents (9 chapters)

Table of contents (9 chapters)
  • Mucosal Delivery Routes for Optimal Immunization: Targeting Immunity to the Right Tissues

    Pages 1-18

    Czerkinsky, C. (et al.)

  • Mucosal Immune Responses Induced by Transcutaneous Vaccines

    Pages 19-37

    Lawson, L. B. (et al.)

  • M Cell-Targeted Mucosal Vaccine Strategies

    Pages 39-52

    Yamamoto, M. (et al.)

  • Virus-Like Particles for Antigen Delivery at Mucosal Surfaces

    Pages 53-73

    Schneider-Ohrum, K. (et al.)

  • Recent Advances in Microparticle and Nanoparticle Delivery Vehicles for Mucosal Vaccination

    Pages 75-99

    McNeela, E. A. (et al.)

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-642-23693-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-642-23692-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-3-642-43923-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mucosal Vaccines
Book Subtitle
Modern Concepts, Strategies, and Challenges
Editors
  • Pamela A. Kozlowski
Series Title
Current Topics in Microbiology and Immunology
Series Volume
354
Copyright
2012
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-23693-8
DOI
10.1007/978-3-642-23693-8
Hardcover ISBN
978-3-642-23692-1
Softcover ISBN
978-3-642-43923-0
Series ISSN
0070-217X
Edition Number
1
Number of Pages
X, 198
Topics

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