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Springer Theses

Theory of Phase Transitions in Polypeptides and Proteins

Authors: Yakubovich, Alexander V.

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  • Nominated as an outstanding contribution by the University of Frankfurt
  • Represents a fertile encounter between physics and life-sciences
  • Presents the first physically motivated quantitative description of the protein folding/unfolding transition
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  • ISBN 978-3-642-22592-5
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  • ISBN 978-3-642-26953-0
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About this book

There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics.
The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.

Table of contents (7 chapters)

Table of contents (7 chapters)

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-3-642-22592-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-642-22591-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $119.99
price for USA in USD
  • ISBN 978-3-642-26953-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the eBook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Theory of Phase Transitions in Polypeptides and Proteins
Authors
Series Title
Springer Theses
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-22592-5
DOI
10.1007/978-3-642-22592-5
Hardcover ISBN
978-3-642-22591-8
Softcover ISBN
978-3-642-26953-0
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XIII, 121
Number of Illustrations
28 b/w illustrations, 11 illustrations in colour
Topics