Regulatory RNAs
Basics, Methods and Applications
Editors: Mallick, Bibekanand, Ghosh, Zhumur (Eds.)
Free Preview- Complete overview on regulatory RNAs
- Includes the basics, methods and applicative areas involving these regulatory RNAs
- Written by international experts
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- About this book
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Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.
- Reviews
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From the reviews:
“The book represents a valuable collection of articles that reflect the current knowledge in the RNAi field. It is useful for both biologists and bioinformaticians, researchers and students alike, and strengthens the links between molecular biology and bioinformatics.” (Irina Ioana Mohorianu, zbMATH, Vol. 1275, 2014)
- Table of contents (21 chapters)
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Renaissance of the Regulatory RNAs
Pages 3-22
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Diversity, Overlap, and Relationships in the Small RNA Landscape
Pages 23-48
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Fragments of Small Nucleolar RNAs as a New Source for Noncoding RNAs
Pages 49-71
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Small Regulatory RNAs (sRNAs): Key Players in Prokaryotic Metabolism, Stress Response, and Virulence
Pages 73-109
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The Canonical RNA Interference Pathway in Animals
Pages 111-149
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Table of contents (21 chapters)
- Download Preface 1 PDF (32.8 KB)
- Download Sample pages 1 PDF (420.9 KB)
- Download Table of contents PDF (25.2 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Regulatory RNAs
- Book Subtitle
- Basics, Methods and Applications
- Editors
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- Bibekanand Mallick
- Zhumur Ghosh
- Copyright
- 2012
- Publisher
- Springer-Verlag Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
- eBook ISBN
- 978-3-642-22517-8
- DOI
- 10.1007/978-3-642-22517-8
- Hardcover ISBN
- 978-3-642-22516-1
- Softcover ISBN
- 978-3-642-44284-1
- Edition Number
- 1
- Number of Pages
- X, 554
- Topics
