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Chemogenomics and Chemical Genetics

A User's Introduction for Biologists, Chemists and Informaticians

Editors: MARECHAL, ERIC, Roy, Sylvaine, Lafanechère, Laurence (Eds.)

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  • Conceived for beginners
  • Not only for medicinal chemists, but any biologist, chemist, mathematician or IT scientist interested in that field
  • Written by experts from both the academic (University) and private (Pharma companies) sectors
  • Shows more applications than just drug discovery
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-19615-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-642-19614-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.99
price for USA in USD
  • ISBN 978-3-662-51991-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently introduced in academic laboratories. High-throughput and high-content screening allow the identification of bioactive compounds in collections of molecules (chemical libraries), being effective on biological targets defined at various organisational scales, from proteins to cells to complete organisms. These bioactive molecules can be therapeutic drug candidates, molecules for biotech, diagnostic or agronomic applications, or tools for basic research. Handling a large number of biological (genomic and post-genomic), chemical and experimental information, screening approaches cannot be envisaged without any electronic storage and mathematical treatment of the data. “Chemogenomics and Chemical Genetics"  is an introductory manual presenting methods and concepts making up the basis for this recent discipline.

This book is dedicated to biologists, chemists and computer scientist beginners. It is organized in brief, illustrated chapters with practical examples. Clear definitions of billogical, chemical and IT concepts are given in a glossary section to help readers who are not familiar with one of these disciplines. "Chemogenomics and Chemical Genetics" should therefore be helpful for students (from Bachelor's degree level), technological platform engineers, and researchers in biology, chemistry, bioinformatics, cheminformatics, both in biotech and academic laboratories.

Table of contents (17 chapters)

Table of contents (17 chapters)
  • The pharmacological screening process: the small molecule, the biological Screen, the robot, the signal and the information

    Pages 7-21

    MarÉchal, Eric (et al.)

  • Collections of molecules for screening: example of the french national chemical library

    Pages 23-28

    Hibert, Marcel

  • The miniaturised biological assay: constraints and limitations

    Pages 29-42

    Knibiehler, Martine

  • The signal: statistical aspects, normalisation, elementary analysis

    Pages 43-53

    Wieczorek, Samuel

  • Measuring Bioactivity: KI, IC50 and EC50

    Pages 55-65

    MarÉchal, Eric

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-19615-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-642-19614-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.99
price for USA in USD
  • ISBN 978-3-662-51991-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chemogenomics and Chemical Genetics
Book Subtitle
A User's Introduction for Biologists, Chemists and Informaticians
Editors
  • ERIC MARECHAL
  • Sylvaine Roy
  • Laurence Lafanechère
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-19615-7
DOI
10.1007/978-3-642-19615-7
Hardcover ISBN
978-3-642-19614-0
Softcover ISBN
978-3-662-51991-2
Edition Number
1
Number of Pages
XI, 256
Additional Information
Original French edition published by EDP Sciences, 2007, Jointly published with Grenoble Sciences
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