Overview
- Gives an insight into clinical trials and novel cell sources for cell therapy
- Covers a complete range of biomaterials, examining different aspects of their application
Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials (SMTEB, volume 6)
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Table of contents (11 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Myocardial tissue engineering (MTE), a concept that intends to prolong patients’ life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered ‘vehicle’, which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book covers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.
Editors and Affiliations
Bibliographic Information
Book Title: Myocardial Tissue Engineering
Editors: Aldo R. Boccaccini, Sian E. Harding
Series Title: Studies in Mechanobiology, Tissue Engineering and Biomaterials
DOI: https://doi.org/10.1007/978-3-642-18056-9
Publisher: Springer Berlin, Heidelberg
eBook Packages: Engineering, Engineering (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2011
Hardcover ISBN: 978-3-642-18055-2Published: 31 August 2011
Softcover ISBN: 978-3-642-26978-3Published: 11 November 2013
eBook ISBN: 978-3-642-18056-9Published: 29 August 2011
Series ISSN: 1868-2006
Series E-ISSN: 1868-2014
Edition Number: 1
Number of Pages: X, 270
Topics: Biomedical Engineering and Bioengineering, Stem Cells, Biomaterials, Gene Therapy, Cardiology