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NF-kB in Health and Disease

  • Book
  • © 2011

Overview

Editors:
  1. Michael Karin

    1. School of Medicine, Dept. Pharmacology, University of California, San Diego, La Jolla, USA

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  • NF-kappaB transcription factors regulate a number of important physiological processes, including inflammation and immune responses, cell growth and survival, and the expression of certain viral genes
  • Moreover, NF-kappaB activity is elevated in and contributes to the pathology of several human diseases, including many cancers and chronic inflammatory diseases
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 349)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Understanding the Logic of IκB:NF-κB Regulation in Structural Terms

    • Tom Huxford, Alexander Hoffmann, Gourisankar Ghosh
    Pages 1-24

  3. NF-κB/Rel Proteins and the Humoral Immune Responses of Drosophila melanogaster

    • Sandhya Ganesan, Kamna Aggarwal, Nicholas Paquette, Neal Silverman
    Pages 25-60

  4. Specialized Chromatin Patterns in the Control of Inflammatory Gene Expression

    • Gioacchino Natoli
    Pages 61-72

  5. IKK Regulation and Human Genetics

    • Gilles Courtois, Alain Israël
    Pages 73-95

  6. Control of NF-κB Activity by Proteolysis

    • Véronique Baud, Emmanuel Derudder
    Pages 97-114

  7. NF-κB and Innate Immunity

    • Anurupa Dev, Shankar Iyer, Bahram Razani, Genhong Cheng
    Pages 115-143

  8. NF-κB and Mucosal Homeostasis

    • Lars Eckmann, Andrew S. Neish
    Pages 145-158

  9. IKK- and NF-κB-Mediated Functions in Carcinogenesis

    • Melek C. Arkan, Florian R. Greten
    Pages 159-169

  10. Macrophages and NF-κB in Cancer

    • Toby Lawrence
    Pages 171-184

  11. NF-κB in Liver Cancer: The Plot Thickens

    • Shlomi Finkin, Eli Pikarsky
    Pages 185-196

  12. NF-κB as a Target for Oncogenic Viruses

    • Shao-Cong Sun, Ethel Cesarman
    Pages 197-244

  13. Inhibition of NF-κB Signaling as a Strategy in Disease Therapy

    • Thomas D. Gilmore, Michael R. Garbati
    Pages 245-263

  14. Back Matter

    Pages 265-268
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Keywords

About this book

Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation

Editors and Affiliations

  • School of Medicine, Dept. Pharmacology, University of California, San Diego, La Jolla, USA

    Michael Karin

Bibliographic Information

  • Book Title: NF-kB in Health and Disease

  • Editors: Michael Karin

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-16017-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2011

  • Hardcover ISBN: 978-3-642-16016-5Published: 06 May 2011

  • Softcover ISBN: 978-3-642-26803-8Published: 15 July 2013

  • eBook ISBN: 978-3-642-16017-2Published: 26 April 2011

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VIII, 268

  • Topics: Cancer Research

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