Carbon Nanotubes for Biomedical Applications

1. Front Matter

   Pages i-xix

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2. Fundamentals: Synthesis of multifunctional nanomaterials and their potential for medical application

   1. Front Matter

      Pages 1-1

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   2. Physical Properties of Carbon Nanotubes for Therapeutic Applications

      • Vittoria Raffa, Orazio Vittorio, Cristina Riggio, Gianni Ciofani, Alfred Cuschieri

      Pages 3-26

   3. Carbon Nanotubes in Regenerative Medicine

      • Bhavna S. Paratala, Balaji Sitharaman

      Pages 27-39

   4. Filling of Carbon Nanotubes with Compounds in Solution or Melted Phase

      • P. Lukanov, C.-M. Tîlmaciu, A. M. Galibert, B. Soula, E. Flahaut

      Pages 41-65

   5. Filling of Carbon Nanotubes: Containers for Magnetic Probes and Drug Delivery

      • E. Borowiak-Palen, C. Tripisciano, M. Rümmeli, S. Costa, X. Chen, R. J. Kalenczuk

      Pages 67-82

3. Magnetically functionalised carbon nanotubes for medical diagnosis and therapy

   1. Front Matter

      Pages 83-83

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   2. Magnetic Nanoparticles for Diagnosis and Medical Therapy

      • Martin Sobik, Kirsten M. Pondman, Ben Erné, Bonny Kuipers, Bennie ten Haken, Horst Rogalla

      Pages 85-95

   3. Feasibility of Magnetically Functionalised Carbon Nanotubes for Biological Applications: From Fundamental Properties of Individual Nanomagnets to Nanoscaled Heaters and Temperature Sensors

      • Matthias U. Lutz, Kamil Lipert, Yulia Krupskaya, Stefan Bahr, Anja Wolter, Ahmed A. El-Gendy et al.

      Pages 97-124

   4. Nuclear Magnetic Resonance Spectroscopy and Imaging of Carbon Nanotubes

      • Vijay K. Anuganti, Aldrik H. Velders

      Pages 125-150

4. Interaction with biological systems

   1. Front Matter

      Pages 151-151

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   2. Exploring Carbon Nanotubes and Their Interaction with Cells Using Atomic Force Microscopy

      • Constanze Lamprecht, Andreas Ebner, Ferry Kienberger, Peter Hinterdorfer

      Pages 153-168

   3. Uptake, Intracellular Localization and Biodistribution of Carbon Nanotubes

      • V. Neves, H. M. Coley, J. McFadden, S. R. P. Silva

      Pages 169-182

   4. Recognition of Carbon Nanotubes by the Human Innate Immune System

      • Malgorzata J. Rybak-Smith, Kirsten M. Pondman, Emmanuel Flahaut, Carolina Salvador-Morales, Robert B. Sim

      Pages 183-210

   5. Toxicity and Environmental Impact of Carbon Nanotubes

      • E. Flahaut

      Pages 211-219

5. Towards targeted chemotherapy and gene delivery

   1. Front Matter

      Pages 221-221

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   2. Carbon Nanotubes Loaded with Anticancer Drugs: A Platform for Multimodal Cancer Treatment

      • Elena Heister, Vera Neves, S. Ravi P. Silva, Johnjoe McFadden, Helen M. Coley

      Pages 223-245

   3. Carbon Nanotubes Filled with Carboplatin: Towards Carbon Nanotube-Supported Delivery of Chemotherapeutic Agents

      • D. Haase, S. Hampel, K. Kraemer, D. Kunze, A. Taylor, M. Arlt et al.

      Pages 247-258

   4. Functionalized Carbon Nanotubes for Gene Biodelivery

      • V. Sanz-Beltrán, Ravi Silva, Helen Coley, Johnjoe McFadden

      Pages 259-273

6. Back Matter

   Pages 275-278

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This book explores the potential of multi-functional carbon nanotubes for biomedical applications. It combines contributions from chemistry, physics, biology, engineering, and medicine. The complete overview of the state-of-the-art addresses different synthesis and biofunctionalisation routes and shows the structural and magnetic properties of nanotubes relevant to biomedical applications. Particular emphasis is put on the interaction of carbon nanotubes with biological environments, i.e. toxicity, biocompatibility, cellular uptake, intracellular distribution, interaction with the immune system and environmental impact. The insertion of NMR-active substances allows diagnostic usage as markers and sensors, e.g. for imaging and contactless local temperature sensing. The potential of nanotubes for therapeutic applications is highlighted by studies on chemotherapeutic drug filling and release, targeting and magnetic hyperthermia studies for anti-cancer treatment at the cellular level.

• NMR-active substances
• biocompatibility
• cellular uptake
• intracellular distribution
• toxicity
• biochemical engineering

• Kirchhoff Institute for Physics, Heidelberg University, Heidelberg, Heidelberg, Germany

  Rüdiger Klingeler

• Department of Pharmacology, Oxford University, Oxford, UK

  Robert B. Sim

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