Current Topics in Microbiology and Immunology

Cancer Immunology and Immunotherapy

Editors: Dranoff, Glenn (Ed.)

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  • The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome.

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About this book

The recent FDA approval of Provenge® as the first therapeutic cancer vaccine together with the recent demonstration that Ipilimumab®, a monoclonal antibody that blocks the negative immune checkpoint cytotoxic T lymphocyte associated antigen-4, prolongs patient survival are major achievements that usher in a new era of cancer immunotherapy. These “first-in-class” treatments reflect the substantive progress that basic and translational scientists have made towards understanding the mechanisms underlying protective tumor immunity in cancer patients Immunotherapies were first explored at the turn of the twentieth century, but the crafting of potent treatments required more detailed knowledge of how the immune system responds to cancer. Advances in genetic, cellular, and biochemical technologies have begun to yield this critical information, focusing attention on immune recognition, regulation, and escape. Indeed, the dynamic interplay of these processes in the tumor microenvironment is now recognized to play a decisive role in determining disease outcome. This volume highlights the rapid progress and breadth of research in cancer immunology, and provides a framework for anticipating many more clinical successes in cancer immunotherapy.

Reviews

From the reviews:

“This book comprises 13 reviews, contributed by members of a cross-section of groups working in the … field of cancer immunology. … this book is at its best when considering small and apparently discrete topics ­­– its strength comes from being able to read all of these ideas on one place. … Overall, this book gives a thorough and detailed overview of the current state of basic and translational research into cancer immunology … . It’s probably most appropriate for researchers … .”­­­ (Victoria Lawson, Immunology News, November, 2011)

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Immune Infiltration in Human Cancer: Prognostic Significance and Disease Control

    Fridman, Wolf H. (et al.)

    Pages 1-24

  • Subversion and Coercion: The Art of Redirecting Tumor Immune Surveillance

    Mumm, John B. (et al.)

    Pages 25-39

  • STAT3: A Target to Enhance Antitumor Immune Response

    Lee, Heehyoung (et al.)

    Pages 41-59

  • Biology and Clinical Observations of Regulatory T Cells in Cancer Immunology

    Teng, Michele W. L. (et al.)

    Pages 61-95

  • Concepts and Ways to Amplify the Antitumor Immune Response

    Rubin, Bent (et al.)

    Pages 97-128

Buy this book

eBook $179.00
price for USA in USD (gross)
  • ISBN 978-3-642-14136-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-642-14135-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $229.99
price for USA in USD
  • ISBN 978-3-642-26788-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cancer Immunology and Immunotherapy
Editors
  • Glenn Dranoff
Series Title
Current Topics in Microbiology and Immunology
Series Volume
344
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-14136-2
DOI
10.1007/978-3-642-14136-2
Hardcover ISBN
978-3-642-14135-5
Softcover ISBN
978-3-642-26788-8
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XIV, 306
Topics