Biocatalysis Based on Heme Peroxidases

1. Front Matter

   Pages i-xi

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2. Molecular and Structural Aspects of Peroxidases

   1. Front Matter

      Pages 5-5

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3. Introduction

   1. Introduction

      • Marcela Ayala, Eduardo Torres

      Pages 1-4

4. Molecular and Structural Aspects of Peroxidases

   1. Front Matter

      Pages 5-5

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   2. Molecular Phylogeny of Heme Peroxidases

      • Marcel Zámocký, Christian Obinger

      Pages 7-35

   3. Structural and Functional Features of Peroxidases with a Potential as Industrial Biocatalysts

      • Francisco J. Ruiz-Dueñas, Angel T. Martínez

      Pages 37-59

   4. Redox Potential of Peroxidases

      • Marcela Ayala

      Pages 61-77

   5. Catalytic Mechanisms of Heme Peroxidases

      • Paul R. Ortiz de Montellano

      Pages 79-107

5. Prospective Usage of Peroxidases in Industry

   1. Front Matter

      Pages 109-109

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   2. Potential Applications of Peroxidases in the Fine Chemical Industries

      • Luigi Casella, Enrico Monzani, Stefania Nicolis

      Pages 111-153

   3. Grafting of Functional Molecules: Insights into Peroxidase-Derived Materials

      • Gibson S. Nyanhongo, Endry Nugroho Prasetyo, Tukayi Kudanga, Georg Guebitz

      Pages 155-177

   4. Applications and Prospective of Peroxidase Biocatalysis in the Environmental Field

      • Cristina Torres-Duarte, Rafael Vazquez-Duhalt

      Pages 179-206

6. Challenges in the Application of Peroxidases

   1. Front Matter

      Pages 207-207

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   2. Enzyme Technology of Peroxidases: Immobilization, Chemical and Genetic Modification

      • Adriana Longoria, Raunel Tinoco, Eduardo Torres

      Pages 209-243

   3. Reactor Engineering

      • Juan M. Lema, Carmen López, Gemma Eibes, Roberto Taboada-Puig, M. Teresa Moreira, Gumersindo Feijoo

      Pages 245-290

   4. Deactivation of Hemeperoxidases by Hydrogen Peroxide: Focus on Compound III

      • Brenda Valderrama

      Pages 291-314

   5. Heterologous Expression of Peroxidases

      • Sandra de Weert, B. Christien Lokman

      Pages 315-333

   6. A Compendium of Bio–Physical–Chemical Properties of Peroxidases

      • Humberto Garcia-Arellano

      Pages 335-352

7. Back Matter

   Pages 353-358

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The last systematic description of heme peroxidases was published in 1999 by Brian Dunford, from the University of Alberta in Canada. The book Heme per- idases covers discussion on three-dimensional structure, reaction mechanism, kinetics, and spectral properties of representative enzymes from bacterial, plant, fungal, and animal origin. Since 1999, vast information on basic but also applied aspects of heme peroxidases has been generated. We believe fusion of these two aspects will bene?t research of those dedicated to development of biocatalytic process. The aim of this book is to present recent advances on basic aspects such as evolution, structure–function relation, and catalytic mechanism, as well as applied aspects, such as bioreactor and protein engineering, in order to provide the tools for rational design of enhanced biocatalysts and biocatalytic processes. The book does not include an exhaustive listing of references but rather a selected collection to enrich discussion and to allow envisioning future directions for research. This book is organized in three parts. In Part I, current knowledge of structure and mechanism of peroxidases is covered. From the molecular phylogeny, going through the in?uence of structural factors over oxidative ability to the molecular mechanism of catalysis, the authors intend to provide an understanding of per- idases at the molecular level. The understanding of the fundamental behavior of peroxidases will allow further adequation, design, and/or optimization of pero- dase-based catalysis to a particular process. In Part II, research on potential applications of peroxidases in several ?elds is presented and discussed.

• Enzyme bioreactor
• Enzyme technology
• Expression
• Heme peroxidases
• biocatalysis
• biotechnology
• catalysis
• evolution
• genetic modification
• peroxidases
• phylogeny
• protein
• reaction

• , Centro de Química, Benemérita Universidad Autónoma de Puebl, Puebla, Mexico

  Eduardo Torres

• , Biotechnology Institute, Autonomous University of Mexico, Cuernavaca, Morelos, Mexico

  Marcela Ayala

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