Read While You Wait - Get immediate ebook access, if available*, when you order a print book

Laron Syndrome - From Man to Mouse

Lessons from Clinical and Experimental Experience

Editors: Laron, Zvi, Kopchick, J. (Eds.)

Free Preview
  • First book covering this interesting topic, written by Zvi Laron who first described and reported the condition in 1966 (this syndrome is named after him)
  • Describes the comprehensive pathophysiology of IGF-I deficiency and gives valuable advice for the IGF-I treatment
  • Compares IGF-I and GH deficiency and illustrates the effects of the treatment, e.g. metabolic effects, adipose tissue alterations and the effects on aging
see more benefits

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-3-642-11183-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-642-11182-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Online orders shipping within 2-3 days.
Softcover $279.99
price for USA in USD
  • ISBN 978-3-662-50171-9
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Rent the eBook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
About this book

Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.

Table of contents (59 chapters)

Table of contents (59 chapters)

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-3-642-11183-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-642-11182-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Online orders shipping within 2-3 days.
Softcover $279.99
price for USA in USD
  • ISBN 978-3-662-50171-9
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Rent the eBook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Laron Syndrome - From Man to Mouse
Book Subtitle
Lessons from Clinical and Experimental Experience
Editors
  • Zvi Laron
  • J. Kopchick
Copyright
2011
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-11183-9
DOI
10.1007/978-3-642-11183-9
Hardcover ISBN
978-3-642-11182-2
Softcover ISBN
978-3-662-50171-9
Edition Number
1
Number of Pages
XIV, 531
Topics

*immediately available upon purchase as print book shipments may be delayed due to the COVID-19 crisis. ebook access is temporary and does not include ownership of the ebook. Only valid for books with an ebook version. Springer Reference Works are not included.