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Current Topics in Microbiology and Immunology

Immunological Synapse

Editors: Saito, Takashi, Batista, Facundo D. (Eds.)

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About this book

The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide–MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCR recognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide–MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide– MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response.

Table of contents (12 chapters)

Table of contents (12 chapters)
  • Insights into Function of the Immunological Synapse from Studies with Supported Planar Bilayers

    Pages 1-24

    Dustin, Michael L.

  • Immunological Synapses Within Context: Patterns of Cell–Cell Communication and Their Application in T–T Interactions

    Pages 25-50

    Doh, Junsang (et al.)

  • Molecular and Cellular Dynamics at the Early Stages of Antigen Encounter: The B-Cell Immunological Synapse

    Pages 51-62

    Carrasco, Yolanda R.

  • Inhibitory and Regulatory Immune Synapses

    Pages 63-79

    Eissmann, Philipp (et al.)

  • The Immunological Synapse, TCR Microclusters, and T Cell Activation

    Pages 81-107

    Yokosuka, Tadashi (et al.)

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-642-03858-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-642-03857-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-642-26185-5
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Immunological Synapse
Editors
  • Takashi Saito
  • Facundo D. Batista
Series Title
Current Topics in Microbiology and Immunology
Series Volume
340
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-03858-7
DOI
10.1007/978-3-642-03858-7
Hardcover ISBN
978-3-642-03857-0
Softcover ISBN
978-3-642-26185-5
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XV, 255
Number of Illustrations
5 b/w illustrations, 25 illustrations in colour
Topics

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