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Sepsis Management

PIRO and MODS

  • Book
  • © 2012

Overview

Editors:
  1. Jordi Rello

    1. Unidad de Cuidados Críticos, Hospital Universitari Joan XXIII, Tarragona, Spain

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  2. J. Lipman

    1. Intensive Care Facility, Royal Brisbane Hospital, Herston, Brisbane, Australia

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  3. Thiago Lisboa

    1. Unidad de Cuidados Críticos, Hospital Universitari Joan XXIII, Tarragona, Spain

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  • Offers many new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis

  • Approaches MODS from the perspective of its pathophysiological mechanism and addresses aspects often overlooked in the literature

  • Explores the significance of the PIRO model in the development of effective treatment strategies

  • Written by eminent experts from Europe and beyond

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-vi
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  2. Multiorgan Dysfunction Syndrome (MODS): What is New?

    • Jean-Louis Vincent, Marjorie Beumier, Antoine Herpain, Katia Donadello
    Pages 1-6

  3. MODS Scores: Which One Should I Use?

    • Rui Moreno, Andrew Rhodes
    Pages 7-22

  4. Why Guidelines Require Reform

    • Andrew Rhodes, Maurizio Cecconi, Rui Moreno
    Pages 23-31

  5. PIRO Concept and Clinical Failure

    • Thiago Lisboa, Jordi Rello
    Pages 33-39

  6. PIRO-Based Approach for Sepsis in Immunocompromised Patients: What’s Different?

    • Jorge I. F. Salluh, Fernando Augusto Bozza, André Miguel Japiassu, Márcio Soares
    Pages 41-58

  7. Intra-Abdominal Hypertension and MODS

    • Jan J. De Waele, Inneke De laet
    Pages 59-71

  8. Assessing Renal Dysfunction in Septic Patients

    • Gordon Y. S. Choi, Gavin M. Joynt, Charles D. Gomersall
    Pages 73-90

  9. Monitoring Myocardial Dysfunction as Part of Sepsis Management

    • Olfa Hamzaoui, Jean-Louis Teboul
    Pages 91-102

  10. The Lung in Multiorgan Failure

    • Rob Boots
    Pages 103-128

  11. Pathogens in Severe Sepsis: New Paradigms for Gram-Positive Treatment

    • Lee P. Skrupky, Scott T. Micek, Marin H. Kollef
    Pages 129-147

  12. Pathogens in Severe Sepsis: New Paradigms for Fungi Treatment

    • Matteo Bassetti, Malgorzata Mikulska
    Pages 149-170

  13. Importance of High Creatinine Clearance for Antibacterial Treatment in Sepsis

    • Jeffrey Lipman, Andrew Udy
    Pages 171-197

  14. How do I Adjust Antimicrobial Daily Dosage in Patients with MODS? A Pharmacist’s Contribution

    • Marta Ulldemolins, Jason A. Roberts
    Pages 199-217

  15. Improving Outcomes in Sepsis and Septic Shock: Getting it Right the First Time

    • Duane Funk, Shravan Kethireddy, Anand Kumar
    Pages 219-235

  16. Back Matter

    Pages 237-243
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Keywords

About this book

This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.

Editors and Affiliations

  • Unidad de Cuidados Críticos, Hospital Universitari Joan XXIII, Tarragona, Spain

    Jordi Rello, Thiago Lisboa

  • Intensive Care Facility, Royal Brisbane Hospital, Herston, Brisbane, Australia

    J. Lipman

About the editors

Drs. Rello, Lipman and Lisboa participate in several critical care meetings with lectures on sepsis, antibiotic treatment and organ dysfunction. Every year they organize a meeting in Tarragona, Spain on the management of sepsis.

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