CYBER DEAL: 50% off all Springer eBooks | Get this offer!

Current Topics in Microbiology and Immunology

Toll-like Receptors: Roles in Infection and Neuropathology

Editors: Kielian, Tammy (Ed.)

Free Preview

Buy this book

eBook $189.00
price for USA in USD
  • ISBN 978-3-642-00549-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
Softcover $249.99
price for USA in USD
About this book

Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration.

Table of contents (10 chapters)

Table of contents (10 chapters)

Buy this book

eBook $189.00
price for USA in USD
  • ISBN 978-3-642-00549-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
Softcover $249.99
price for USA in USD
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Toll-like Receptors: Roles in Infection and Neuropathology
Editors
  • Tammy Kielian
Series Title
Current Topics in Microbiology and Immunology
Series Volume
336
Copyright
2009
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-00549-7
DOI
10.1007/978-3-642-00549-7
Hardcover ISBN
978-3-642-00548-0
Softcover ISBN
978-3-642-26911-0
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XI, 191
Number of Illustrations
8 illustrations in colour
Topics