Overview
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 333)
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About this book
Recent years have seen unprecedented outbreaks of avian influenza A viruses. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans, resulting in numerous fatalities. The rapid expansion in their geographic distribution and the possibility that these viruses could acquire the ability to spread from person to person raises the risk that such a virus could cause a global pandemic with high morbidity and mortality. An effective influenza vaccine represents the best approach to prevent and control such an emerging pandemic. However, current influenza vaccines are directed at existing seasonal influenza viruses, which have little or no antigenic relationship to the highly pathogenic H5N1 strains. Concerns about pandemic preparedness have greatly stimulated research activities to develop eff- tive vaccines for pandemic influenza viruses, and to overcome the limitations inh- ent in current approaches to vaccine production and distribution. These limitations include the use of embryonated chicken eggs as the substrate for vaccine prod- tion, which is time-consuming and could involve potential biohazards in growth of new virus strains. Other limitations include the requirement that the current inac- vated influenza vaccines be administered using needles and syringes, requiring trained personnel, which could be a bottleneck when attempting to vaccinate large populations in mass campaigns. In addition, the current inactivated vaccines that are delivered by injection elicit limited protective immunity in the upper respiratory tract where the infection process is initiated.
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Table of contents (24 chapters)
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Front Matter
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Pandemic Influenza Overview
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Front Matter
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Current Approaches for Human and Avian Vaccine Production
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Front Matter
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Novel Vaccine Approaches
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Front Matter
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Editors and Affiliations
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Bibliographic Information
Book Title: Vaccines for Pandemic Influenza
Editors: Richard W. Compans, Walter A. Orenstein
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-540-92165-3
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2009
Hardcover ISBN: 978-3-540-92164-6Published: 28 July 2009
Softcover ISBN: 978-3-642-24240-3Published: 29 November 2011
eBook ISBN: 978-3-540-92165-3Published: 18 September 2009
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: XVIII, 512
Number of Illustrations: 21 b/w illustrations, 30 illustrations in colour
Topics: Virology, Pharmacology/Toxicology, Public Health, Immunology