Handbook of Experimental Pharmacology

Adenosine Receptors in Health and Disease

Editors: Wilson, Constance N., Mustafa, S. Jamal (Eds.)

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About this book

Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Introduction to Adenosine Receptors as Therapeutic Targets

    Pages 1-24

    Jacobson, Kenneth A.

  • A1 Adenosine Receptor Antagonists, Agonists, and Allosteric Enhancers

    Pages 25-58

    Kiesman, William F. (et al.)

  • Recent Developments in Adenosine A2A Receptor Ligands

    Pages 59-98

    Cristalli, Gloria (et al.)

  • Recent Developments in A2B Adenosine Receptor Ligands

    Pages 99-122

    Kalla, Rao V. (et al.)

  • Medicinal Chemistry of the A3 Adenosine Receptor: Agonists, Antagonists, and Receptor Engineering

    Pages 123-159

    Jacobson, Kenneth A. (et al.)

Buy this book

eBook $389.00
price for USA in USD
  • ISBN 978-3-540-89615-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $599.99
price for USA in USD
Softcover $499.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Adenosine Receptors in Health and Disease
Editors
  • Constance N. Wilson
  • S. Jamal Mustafa
Series Title
Handbook of Experimental Pharmacology
Series Volume
193
Copyright
2009
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-89615-9
DOI
10.1007/978-3-540-89615-9
Hardcover ISBN
978-3-540-89614-2
Softcover ISBN
978-3-662-50162-7
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XIII, 652
Topics