Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (13 chapters)
-
Front Matter
-
Back Matter
About this book
This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.
Reviews
From the reviews:
“This monograph is an up to date account of the abnormalities in axonal transport of proteins and molecules in neurons in the aging and diseased brain. … This book is meant for neuropathologists, neurologists, and advanced graduate students in the Neurosciences. I can recommend it for these professionals without hesitation.” (Joseph J. Grenier, Amazon.com, November, 2013)Editors and Affiliations
-
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
Peter H. St. George-Hyslop
-
Department of Neurology, Standford University School of Medicine, Standford, USA
William C. C. Mobley
-
Fondation IPSEN Pour la Recherche Thérapeutique, Boulogne Billancourt, Cedex - France
Yves Christen
Bibliographic Information
Book Title: Intracellular Traffic and Neurodegenerative Disorders
Editors: Peter H. St. George-Hyslop, William C. C. Mobley, Yves Christen
Series Title: Research and Perspectives in Alzheimer's Disease
DOI: https://doi.org/10.1007/978-3-540-87941-1
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2009
Hardcover ISBN: 978-3-540-87940-4Published: 10 December 2008
Softcover ISBN: 978-3-642-09972-4Published: 25 November 2010
eBook ISBN: 978-3-540-87941-1Published: 03 February 2009
Series ISSN: 0945-6066
Series E-ISSN: 2196-310X
Edition Number: 1
Number of Pages: XIV, 184
Number of Illustrations: 11 b/w illustrations, 25 illustrations in colour
Topics: Neurosciences