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Handbook of Experimental Pharmacology

Pharmacology and Therapeutics of Cough

Editors: Chung, K. Fan, Widdicombe, John (Eds.)

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About this book

The last decade or so has seen remarkable advances in our knowledge of cough. This applies especially to its basic mechanisms: the types of airway sensors, the phar- cological receptors on their membranes, the brainstem organization of the ‘cough centre’, and the involvement of the cerebral cortex in the sensations and the vol- tary control of cough. With the exception of the last of these, nearly all the studies have been on experimental animals rather than humans, for obvious reasons. One group of experimental studies has particular relevance to human patients, and that is the demonstration of the sensitization of cough pathways both in the periphery and in the brainstem. Similar sensitizations have been shown for patients with chronic cough or who have been exposed to pollutants, and it is reasonable to suppose that this is the basis of their cough and that the underlying mechanisms are generally similar in humans and other species. Important advances are also being made in clinical cough research. For the three main causes of clinical cough, asthma, post-nasal drip syndrome, and gast- oesophageal re?ux disease, we are beginning to understand the pathological processes involved. There remains a diagnostically obdurate group of idiopathic chronic coughers, but even for them approaches are being devised to clarify und- lying mechanisms and to establish diagnoses. Perhaps surprisingly, the ?eld in which there has been the least spectacular - vance is the therapy of cough.

Table of contents (18 chapters)

Table of contents (18 chapters)
  • Cough: Setting the Scene

    Pages 1-21

    Chung, K. F. (et al.)

  • Cough Sensors. I. Physiological and Pharmacological Properties of the Afferent Nerves Regulating Cough

    Pages 23-47

    Canning, B. J. (et al.)

  • Cough Sensors. II. Transient Receptor Potential Membrane Receptors on Cough Sensors

    Pages 49-61

    Materazzi, S. (et al.)

  • Cough Sensors. III. Opioid and Cannabinoid Receptors on Vagal Sensory Nerves

    Pages 63-76

    Belvisi, M. G. (et al.)

  • Cough Sensors. IV. Nicotinic Membrane Receptors on Cough Sensors

    Pages 77-98

    Lee, L. -Y. (et al.)

Buy this book

eBook $309.00
price for USA in USD (gross)
  • ISBN 978-3-540-79842-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $499.99
price for USA in USD
  • ISBN 978-3-540-79841-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $399.99
price for USA in USD
  • ISBN 978-3-642-09857-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pharmacology and Therapeutics of Cough
Editors
  • K. Fan Chung
  • John Widdicombe
Series Title
Handbook of Experimental Pharmacology
Series Volume
187
Copyright
2009
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-79842-2
DOI
10.1007/978-3-540-79842-2
Hardcover ISBN
978-3-540-79841-5
Softcover ISBN
978-3-642-09857-4
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XII, 376
Number of Illustrations
36 b/w illustrations, 3 illustrations in colour
Topics