Current Topics in Microbiology and Immunology

Human Cytomegalovirus

Editors: Shenk, Thomas E., Stinski, Mark F. (Eds.)

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About this book

The earliest observation of cytomegalovirus (CMV) interactions with the host cell was owl eye cytopathology in various tissues. It was recognized in the early 1970s that human CMV caused in utero infections resulting in congenital brain damage and other sensory neurological complications. Events of the 1980s and early 1990s, such as the wide application of solid organ and bone marrow transplantation and the emergence of AIDS, put the spotlight on human CMV. We understood that the virus was an opportunistic agent associated with immunosuppression. The golden age of cytomegalovirus research was ushered in during the late 1970s and early 1980s by a set of powerful new technologies that included restriction enzymes, DNA cloning, DNA sequencing, and open reading frame prediction. The genetic manipulation and propagation of novel CMV strains was accelerated with the app- cation of bacterial artificial chromosome technology. Today, we still struggle to understand the full spectrum of disease associated with human CMV. To the molecular biologist, CMV is a master of regulation in the eukaryotic cell where it either replicates or remains latent. To the immunologist, CMV is a master of immune evasion with tools to escape both the innate and acquired immune responses. The use of animal models with non-human CMVs has become significantly more sophisticated and tied to a more certain understanding of the interrelationships of non-human and human CMV genes.

Table of contents (23 chapters)

Table of contents (23 chapters)

Buy this book

eBook $179.00
price for USA in USD (gross)
  • ISBN 978-3-540-77349-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-540-77348-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $229.99
price for USA in USD
  • ISBN 978-3-642-44513-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Human Cytomegalovirus
Editors
  • Thomas E. Shenk
  • Mark F. Stinski
Series Title
Current Topics in Microbiology and Immunology
Series Volume
325
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-77349-8
DOI
10.1007/978-3-540-77349-8
Hardcover ISBN
978-3-540-77348-1
Softcover ISBN
978-3-642-44513-2
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XIII, 479
Topics