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Human Cytomegalovirus

  • Book
  • © 2008

Overview

Editors:
  1. Thomas E. Shenk

    1. Princeton University, Princeton, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Mark F. Stinski

    1. University of Iowa, Iowa, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 325)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Human Cytomegalovirus Genome

    • E. Murphy, Thomas E. Shenk
    Pages 1-19

  3. Human Cytomegalovirus microRNAs

    • P. J. Fannin Rider, W. Dunn, E. Yang, F. Liu
    Pages 21-39

  4. Mutagenesis of the Cytomegalovirus Genome

    • Z. Ruzsics, U. H. Koszinowski
    Pages 41-61

  5. Cytomegalovirus Cell Tropism

    • C. Sinzger, M. Digel, G. Jahn
    Pages 63-83

  6. Virus Entry and Innate Immune Activation

    • M. K. Isaacson, L. K. Juckem, T. Compton
    Pages 85-100

  7. Functions of Human Cytomegalovirus Tegument Proteins Prior to Immediate Early Gene Expression

    • R. F. Kalejta
    Pages 101-115

  8. Initiation of Cytomegalovirus Infection at ND10

    • G. G. Maul
    Pages 117-132

  9. Functional Roles of the Human Cytomegalovirus Essential IE86 Protein

    • Mark F. Stinski, D. T. Petrik
    Pages 133-152

  10. Nuts and Bolts of Human Cytomegalovirus Lytic DNA Replication

    • G. S. Pari
    Pages 153-166

  11. Interactions of Human Cytomegalovirus Proteins with the Nuclear Transport Machinery

    • T. Stamminger
    Pages 167-185

  12. Structure and Formation of the Cytomegalovirus Virion

    • W. Gibson
    Pages 187-204

  13. Human Cytomegalovirus Modulation of Signal Transduction

    • A. D. Yurochko
    Pages 205-220

  14. Chemokines and Chemokine Receptors Encoded by Cytomegaloviruses

    • P. S. Beisser, H. Lavreysen, C. A. Bruggeman, C. Vink
    Pages 221-242

  15. Subversion of Cell Cycle Regulatory Pathways

    • V. Sanchez, D. H. Spector
    Pages 243-262

  16. Modulation of Host Cell Stress Responses by Human Cytomegalovirus

    • J. C. Alwine
    Pages 263-279

  17. Control of Apoptosis by Human Cytomegalovirus

    • A. L. McCormick
    Pages 281-295

  18. Aspects of Human Cytomegalovirus Latency and Reactivation

    • M. Reeves, J. Sinclair
    Pages 297-313

  19. Murine Model of Cytomegalovirus Latency and Reactivation

    • M. J. Reddehase, C. O. Simon, C. K. Seckert, N. Lemmermann, N. K. A. Grzimek
    Pages 315-331

  20. Cytomegalovirus Immune Evasion

    • C. Powers, V. DeFilippis, D. Malouli, K. Früh
    Pages 333-359
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Keywords

About this book

The earliest observation of cytomegalovirus (CMV) interactions with the host cell was owl eye cytopathology in various tissues. It was recognized in the early 1970s that human CMV caused in utero infections resulting in congenital brain damage and other sensory neurological complications. Events of the 1980s and early 1990s, such as the wide application of solid organ and bone marrow transplantation and the emergence of AIDS, put the spotlight on human CMV. We understood that the virus was an opportunistic agent associated with immunosuppression. The golden age of cytomegalovirus research was ushered in during the late 1970s and early 1980s by a set of powerful new technologies that included restriction enzymes, DNA cloning, DNA sequencing, and open reading frame prediction. The genetic manipulation and propagation of novel CMV strains was accelerated with the app- cation of bacterial artificial chromosome technology. Today, we still struggle to understand the full spectrum of disease associated with human CMV. To the molecular biologist, CMV is a master of regulation in the eukaryotic cell where it either replicates or remains latent. To the immunologist, CMV is a master of immune evasion with tools to escape both the innate and acquired immune responses. The use of animal models with non-human CMVs has become significantly more sophisticated and tied to a more certain understanding of the interrelationships of non-human and human CMV genes.

Editors and Affiliations

  • Princeton University, Princeton, USA

    Thomas E. Shenk

  • University of Iowa, Iowa, USA

    Mark F. Stinski

Bibliographic Information

  • Book Title: Human Cytomegalovirus

  • Editors: Thomas E. Shenk, Mark F. Stinski

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-540-77349-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2008

  • Hardcover ISBN: 978-3-540-77348-1Published: 12 June 2008

  • Softcover ISBN: 978-3-642-44513-2Published: 28 November 2014

  • eBook ISBN: 978-3-540-77349-8Published: 09 May 2008

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIII, 479

  • Topics: Virology

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